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Home › Dataset Library › Transcription profiling by array of human glioblastoma cell lines

Dataset: Transcription profiling by array of human glioblastoma cell lines

Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions...

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Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. Microarray analysis showed that the 4 GSf cell lines shared expression profiles dominated by genes involved in nervous system development and neuropeptide signaling, while the 5 GSr lines shared expression signatures enriched for extracellular matrix-proteins. Experiment Overall Design: Affymetrix HG-U133 Plus 2.0 chips were employed for expression profiling from 9 different glioblasoma derived neurosphere cultures in two biological replicates.

Species:
human

Samples:
17

Source:
E-GEOD-8049

PubMed:
18037961

Updated:
Dec.12, 2014

Registered:
Sep.22, 2014


Factors: (via ArrayExpress)
Sample cell line
GSE8049GSM198767 GS-3
GSE8049GSM198767 GS-3
GSE8049GSM198769 GS-5
GSE8049GSM198769 GS-5
GSE8049GSM198772 GS-8
GSE8049GSM198772 GS-8
GSE8049GSM198773 GS-9
GSE8049GSM198773 GS-9
GSE8049GSM198765 GS-1
GSE8049GSM198765 GS-1
GSE8049GSM198766 GS-2
GSE8049GSM198766 GS-2
GSE8049GSM198768 GS-4
GSE8049GSM198768 GS-4
GSE8049GSM198770 GS-6
GSE8049GSM198771 GS-7
GSE8049GSM198771 GS-7

Tags

  • cell
  • nervous system
  • stem cell

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