{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 4952, "factors": [{"GSE8049GSM198767": {"cell line": "GS-3"}}, {"GSE8049GSM198767": {"cell line": "GS-3"}}, {"GSE8049GSM198769": {"cell line": "GS-5"}}, {"GSE8049GSM198769": {"cell line": "GS-5"}}, {"GSE8049GSM198772": {"cell line": "GS-8"}}, {"GSE8049GSM198772": {"cell line": "GS-8"}}, {"GSE8049GSM198773": {"cell line": "GS-9"}}, {"GSE8049GSM198773": {"cell line": "GS-9"}}, {"GSE8049GSM198765": {"cell line": "GS-1"}}, {"GSE8049GSM198765": {"cell line": "GS-1"}}, {"GSE8049GSM198766": {"cell line": "GS-2"}}, {"GSE8049GSM198766": {"cell line": "GS-2"}}, {"GSE8049GSM198768": {"cell line": "GS-4"}}, {"GSE8049GSM198768": {"cell line": "GS-4"}}, {"GSE8049GSM198770": {"cell line": "GS-6"}}, {"GSE8049GSM198771": {"cell line": "GS-7"}}, {"GSE8049GSM198771": {"cell line": "GS-7"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions...", "pubmed_id": 18037961, "geo_gse_id": "E-GEOD-8049", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 17, "tags": ["cell", "nervous system", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-8049_A-AFFY-44", "slug": "transcription-profiling-by-array-of-human-gliobl-9", "geo_gds_id": "", "name": "Transcription profiling by array of human glioblastoma cell lines", "created": "Sep.22, 2014", "summary": "Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. Microarray analysis showed that the 4 GSf cell lines shared expression profiles dominated by genes involved in nervous system development and neuropeptide signaling, while the 5 GSr lines shared expression signatures enriched for extracellular matrix-proteins. Experiment Overall Design: Affymetrix HG-U133 Plus 2.0 chips were employed for expression profiling from 9 different glioblasoma derived neurosphere cultures in two biological replicates.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-8049", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-8049/samples/"}