Dataset: Transcription profiling of mouse liver by array

PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by...

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PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by gavage for 7 consecutive days with either 0, 3, or 10 mg/kg PFHxS, or 1 or 3 mg/kg PFNA (#394459, Sigma-Aldrich, St, Louis, MO) in water. PFHxS was kindly provided by 3M Corp (St. Paul, MN). Four biological replicates consisting of individual animals were included in each dose group. Dose levels reflected exposures that produce hepatomegaly in adult mice without inducing overt toxicity.

Species:: mouse
Samples:: 47
Source:: E-GEOD-55756
Updated:: Dec.12, 2014
Registered:: Nov.12, 2014

Factors: (via ArrayExpress)

Sample	COMPOUND	GENETIC BACKGROUND	GENOTYPE	DOSE
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342844	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	10 mg/kg, 7 days
GSM1342844	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	10 mg/kg, 7 days
GSM1342844	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	10 mg/kg, 7 days
GSM1342844	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	10 mg/kg, 7 days
GSM1342848	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342848	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342848	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342848	PFHxS	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342856	PFHxS	129S1/SvlmJ	Wildtype	10 mg/kg, 7 days
GSM1342856	PFHxS	129S1/SvlmJ	Wildtype	10 mg/kg, 7 days
GSM1342856	PFHxS	129S1/SvlmJ	Wildtype	10 mg/kg, 7 days
GSM1342856	PFHxS	129S1/SvlmJ	Wildtype	10 mg/kg, 7 days
GSM1342860	PFHxS	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342860	PFHxS	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342860	PFHxS	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342860	PFHxS	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342864	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	1 mg/kg, 7 days
GSM1342864	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	1 mg/kg, 7 days
GSM1342864	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	1 mg/kg, 7 days
GSM1342864	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	1 mg/kg, 7 days
GSM1342868	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342868	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342868	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342868	PFNA	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	3 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342840	Vehicle	129S4/SvJae-PPARatm1Gonz/J	PPARα-null	0 mg/kg, 7 days
GSM1342876	PFNA	129S1/SvlmJ	Wildtype	1 mg/kg, 7 days
GSM1342876	PFNA	129S1/SvlmJ	Wildtype	1 mg/kg, 7 days
GSM1342876	PFNA	129S1/SvlmJ	Wildtype	1 mg/kg, 7 days
GSM1342879	PFNA	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342879	PFNA	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342879	PFNA	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342879	PFNA	129S1/SvlmJ	Wildtype	3 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days
GSM1342852	Vehicle	129S1/SvlmJ	Wildtype	0 mg/kg, 7 days