Dataset: Transcription profiling of mouse liver by array

PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by...

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PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by gavage for 7 consecutive days with either 0, 3, or 10 mg/kg PFHxS, or 1 or 3 mg/kg PFNA (#394459, Sigma-Aldrich, St, Louis, MO) in water. PFHxS was kindly provided by 3M Corp (St. Paul, MN). Four biological replicates consisting of individual animals were included in each dose group. Dose levels reflected exposures that produce hepatomegaly in adult mice without inducing overt toxicity.

Species:: mouse
Samples:: 47
Source:: E-GEOD-55756
Updated:: Dec.12, 2014
Registered:: Nov.12, 2014

Factors: (via ArrayExpress)

Sample	COMPOUND	DOSE	GENOTYPE	GENETIC BACKGROUND
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342844	PFHxS	10 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342844	PFHxS	10 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342844	PFHxS	10 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342844	PFHxS	10 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342848	PFHxS	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342848	PFHxS	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342848	PFHxS	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342848	PFHxS	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342856	PFHxS	10 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342856	PFHxS	10 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342856	PFHxS	10 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342856	PFHxS	10 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342860	PFHxS	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342860	PFHxS	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342860	PFHxS	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342860	PFHxS	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342864	PFNA	1 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342864	PFNA	1 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342864	PFNA	1 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342864	PFNA	1 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342868	PFNA	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342868	PFNA	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342868	PFNA	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342868	PFNA	3 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342840	Vehicle	0 mg/kg, 7 days	PPARα-null	129S4/SvJae-PPARatm1Gonz/J
GSM1342876	PFNA	1 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342876	PFNA	1 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342876	PFNA	1 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342879	PFNA	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342879	PFNA	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342879	PFNA	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342879	PFNA	3 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ
GSM1342852	Vehicle	0 mg/kg, 7 days	Wildtype	129S1/SvlmJ