ArrayExpress Uploaderarrayexpress_sidmouseVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null10 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null10 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null10 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null10 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFHxS129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype10 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype10 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype10 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype10 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype3 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype3 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype3 mg/kg, 7 daysPFHxS129S1/SvlmJWildtype3 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null1 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null1 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null1 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null1 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysPFNA129S4/SvJae-PPARatm1Gonz/JPPARα-null3 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysVehicle129S4/SvJae-PPARatm1Gonz/JPPARα-null0 mg/kg, 7 daysPFNA129S1/SvlmJWildtype1 mg/kg, 7 daysPFNA129S1/SvlmJWildtype1 mg/kg, 7 daysPFNA129S1/SvlmJWildtype1 mg/kg, 7 daysPFNA129S1/SvlmJWildtype3 mg/kg, 7 daysPFNA129S1/SvlmJWildtype3 mg/kg, 7 daysPFNA129S1/SvlmJWildtype3 mg/kg, 7 daysPFNA129S1/SvlmJWildtype3 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 daysVehicle129S1/SvlmJWildtype0 mg/kg, 7 days759106PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by...E-GEOD-55756/profile/8773/arrayexpressuploader447Dec.12, 2014FalseE-GEOD-55756_A-AFFY-45transcription-profiling-of-mouse-liver-by-arrayTranscription profiling of mouse liver by arrayNov.12, 2014PPARα-null and wild-type male mice treated with PFHxS or PFNA PPARα-null and wild-type male mice at 6-9 months of age were dosed by gavage for 7 consecutive days with either 0, 3, or 10 mg/kg  PFHxS, or 1 or 3 mg/kg PFNA (#394459, Sigma-Aldrich, St, Louis, MO) in water.  PFHxS was kindly provided by 3M Corp (St. Paul, MN).  Four biological replicates consisting of individual animals were included in each dose group.  Dose levels reflected exposures that produce hepatomegaly in adult mice without inducing overt toxicity.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55756http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-55756/samples/