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Home › Dataset Library › Comparison of the transcriptome of TEL-JAK2- versus activated NOTCH1 (ICN1)-induced T cell acute lymphoblastic leukemias (mouse)

Dataset: Comparison of the transcriptome of TEL-JAK2- versus activated NOTCH1 (ICN1)-induced T cell acute lymphoblastic leukemias (mouse)

The TEL-JAK2 fusion oncogene and the ICN1 activated allele of NOTCH1 are the result of specific chromosomal translocations in T cell...

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The TEL-JAK2 fusion oncogene and the ICN1 activated allele of NOTCH1 are the result of specific chromosomal translocations in T cell acute lymphoblastic leukemia (T-ALL). Mouse models of these diseases (TEL-JAK2 transgenic mice; Carron C. et al. Blood (2000); a bone marrow transplantation model for ICN1-induced T-ALL) were used to compare the transcriptional program specific to each oncoprotein in mouse models of these leukemias. Tumor load was >50% leukemic cells in all selected organs. Leukemic cells were collected from the thymus of terminally-ill TEL-JAK2 leukemic mice and bone marrow of terminally-ill ICN1 leukemic mice. RNA was extracted from each sample and processed for hybridization to Affymetrix arrays.

Species:
mouse

Samples:
7

Source:
E-GEOD-51243

Updated:
Dec.12, 2014

Registered:
Nov.12, 2014


Factors: (via ArrayExpress)
Sample GENOTYPE ORGANISM PART
GSM1240952 ICN1 bone marrow
GSM1240952 ICN1 bone marrow
GSM1240952 ICN1 bone marrow
GSM1240955 TEL-JAK2 thymus
GSM1240955 TEL-JAK2 thymus
GSM1240955 TEL-JAK2 thymus
GSM1240955 TEL-JAK2 thymus

Tags

  • acute lymphoblastic leukemia
  • bone
  • bone marrow
  • cell
  • leukemia
  • lymphoblastic leukemia
  • thymus

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