ArrayExpress Uploader0mouseICN1bone marrowICN1bone marrowICN1bone marrowTEL-JAK2thymusTEL-JAK2thymusTEL-JAK2thymusTEL-JAK2thymus7449arrayexpress_sid6The TEL-JAK2 fusion oncogene and the ICN1 activated allele of NOTCH1 are the result of specific chromosomal translocations in T cell...E-GEOD-51243/profile/8773/arrayexpressuploader27acute lymphoblastic leukemiabonebone marrowcellleukemialymphoblastic leukemiathymusDec.12, 2014FalseE-GEOD-51243_A-AFFY-45comparison-of-the-transcriptome-of-tel-jak2-versusComparison of the transcriptome of TEL-JAK2- versus activated NOTCH1 (ICN1)-induced T cell acute lymphoblastic leukemias (mouse)Nov.12, 2014The TEL-JAK2 fusion oncogene and the ICN1 activated allele of NOTCH1 are the result of specific chromosomal translocations in T cell acute lymphoblastic leukemia (T-ALL). Mouse models of these diseases (TEL-JAK2 transgenic mice; Carron C. et al. Blood (2000); a bone marrow transplantation model for ICN1-induced T-ALL) were used to compare the transcriptional program specific to each oncoprotein in mouse models of these leukemias. Tumor load was >50% leukemic cells in all selected organs. Leukemic cells were collected from the thymus of terminally-ill TEL-JAK2 leukemic mice and bone marrow of terminally-ill ICN1 leukemic mice. RNA was extracted from each sample and processed for hybridization to Affymetrix arrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-51243http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-51243/samples/