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Home › Dataset Library › Expression data from mobilized human CD34+ cells

Dataset: Expression data from mobilized human CD34+ cells

Bortezomib-based secondary induction therapy and mobilization could represent alternative strategies to reduce tumor burden. We used...

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Bortezomib-based secondary induction therapy and mobilization could represent alternative strategies to reduce tumor burden. We used microarrays to investigate genome-wide expression changes between bortezomib and non-bortzomib mobilizaton strategies and identified distinct genes and pathways that were significantly differentially regulated. CD34+ stem cells were enriched from leukapheresis products from multiple myeloma patients treated with a bortezomib- or non-bortezomib-based mobilization. RNA extraction, amplification and hybridization on Affymetrix microarrays was performed. Post-induction stem cell collection was initiated when patients' ANC reached >1.0×10^9/L.

Species:
human

Samples:
8

Source:
E-GEOD-43124

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample TREATMENT
GSM1057009 non-bortezomib-based mobilization
GSM1057009 non-bortezomib-based mobilization
GSM1057009 non-bortezomib-based mobilization
GSM1057006 bortezomib-based mobilization
GSM1057006 bortezomib-based mobilization
GSM1057006 bortezomib-based mobilization
GSM1057006 bortezomib-based mobilization
GSM1057006 bortezomib-based mobilization

Tags

  • cell
  • genome
  • multiple myeloma
  • myeloma
  • stem cell

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