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Home › Dataset Library › Effects of Cellular Senescence on Human Mesenchymal Stem Cells

Dataset: Effects of Cellular Senescence on Human Mesenchymal Stem Cells

In the present study we analyzed the effect of cellular senescence on the transcriptome of human mesenchymal stem cells (hMSC;...

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In the present study we analyzed the effect of cellular senescence on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from bone marrow. Human MSC were isolated from femoral heads of non-osteoporotic donors after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Bone marrow was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. MSC were replated after reaching 70-90% confluence until they entered state of cellular senescence. RNA samples of control cells were taken from passage 1 or passage 2.

Species:
human

Samples:
10

Source:
E-GEOD-35957

Updated:
Dec.12, 2014

Registered:
Sep.19, 2014


Factors: (via ArrayExpress)
Sample SAMPLE ID GENDER AGE PASSAGE
GSM878095 donor 1 (MSC population #276) female 42 yrs (middle-aged) passage 1
GSM878096 donor 2 (MSC population #353) female 67 yrs (middle-aged) passage 2
GSM878097 donor 3 (MSC population #295) male 61 yrs (middle-aged) passage 1
GSM878098 donor 4 (MSC population #296) female 62 yrs (middle-aged) passage 1
GSM878099 donor 5 (MSC population #247) female 56 yrs (middle-aged) passage 1
GSM878109 donor 1 (MSC population #276) female 42 yrs long term-cultivation (cellular senescence state)
GSM878110 donor 2 (MSC population #278) female 59 yrs long term-cultivation (cellular senescence state)
GSM878 donor 3 (MSC population #271) female 64 yrs long term-cultivation (cellular senescence state)
GSM878112 donor 4 (MSC population #277) male 54 yrs long term-cultivation (cellular senescence state)
GSM878113 donor 5 (MSC population #274) male 63 yrs long term-cultivation (cellular senescence state)

Tags

  • bone
  • bone marrow
  • hip
  • osteoarthritis

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