Dataset: Effects of Cellular Senescence on Human Mesenchymal Stem Cells
In the present study we analyzed the effect of cellular senescence on the transcriptome of human mesenchymal stem cells (hMSC;...
In the present study we analyzed the effect of cellular senescence on the transcriptome of human mesenchymal stem cells (hMSC; alternatively named mesenchymal stromal cells) from bone marrow. Human MSC were isolated from femoral heads of non-osteoporotic donors after total hip arthroplasty. Cells were isolated from human bone marrow according to the previously described protocol (Noth et al., 2002, J Orthop Res, 20/5, 1060-1069) under agreement of the local Ethics Committee of the University of Würzburg. Bone marrow was obtained of femoral heads after total hip arthroplasty due to osteoarthritis and/or hip dysplasia. MSC were replated after reaching 70-90% confluence until they entered state of cellular senescence. RNA samples of control cells were taken from passage 1 or passage 2.
- Species:
- human
- Samples:
- 10
- Source:
- E-GEOD-35957
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
Sample | SAMPLE ID | GENDER | AGE | PASSAGE |
---|---|---|---|---|
GSM878095 | donor 1 (MSC population #276) | female | 42 yrs (middle-aged) | passage 1 |
GSM878096 | donor 2 (MSC population #353) | female | 67 yrs (middle-aged) | passage 2 |
GSM878097 | donor 3 (MSC population #295) | male | 61 yrs (middle-aged) | passage 1 |
GSM878098 | donor 4 (MSC population #296) | female | 62 yrs (middle-aged) | passage 1 |
GSM878099 | donor 5 (MSC population #247) | female | 56 yrs (middle-aged) | passage 1 |
GSM878109 | donor 1 (MSC population #276) | female | 42 yrs | long term-cultivation (cellular senescence state) |
GSM878110 | donor 2 (MSC population #278) | female | 59 yrs | long term-cultivation (cellular senescence state) |
GSM878 | donor 3 (MSC population #271) | female | 64 yrs | long term-cultivation (cellular senescence state) |
GSM878112 | donor 4 (MSC population #277) | male | 54 yrs | long term-cultivation (cellular senescence state) |
GSM878113 | donor 5 (MSC population #274) | male | 63 yrs | long term-cultivation (cellular senescence state) |