Dataset: Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells
To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and...
To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression. Two repressive histone modifications (H3K9m3 and H3K27m3) , cytosine methylation and gene expression were compared between normal human urothelial cell line (NHU) and malignant urothelial cells (EJ and RT112).
- Dec.12, 2014
- Sep.16, 2014
|Sample||CELL LINE||CELL TYPE|
|GSM790400||EJ1||Human bladder carcinoma, fast growing tumour|
|GSM79040||NHU||Normal human urothelial cell line, moderate growth|
|GSM790402||RT112||Human bladder carcinoma, relatively fast growing tumour|