{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM790400": {"CELL LINE": "EJ1", "CELL TYPE": "Human bladder carcinoma, fast growing tumour"}}, {"GSM79040": {"CELL LINE": "NHU", "CELL TYPE": "Normal human urothelial cell line, moderate growth"}}, {"GSM790402": {"CELL LINE": "RT112", "CELL TYPE": "Human bladder carcinoma, relatively fast growing tumour"}}], "id": 4222, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and...", "geo_gse_id": "E-GEOD-31864", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 3, "tags": ["cancer", "cell", "cytosine", "histone", "line", "urothelium"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "epigenome-profiling-of-repressive-histone-modifica", "geo_id_plat": "E-GEOD-31864_A-AFFY-44", "name": "Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells", "created": "Sep.16, 2014", "summary": "To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression. Two repressive histone modifications (H3K9m3 and H3K27m3) , cytosine methylation and gene expression were compared between normal human urothelial cell line (NHU) and malignant urothelial cells (EJ and RT112).", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31864", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-31864/samples/"}