Dataset: Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells

To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium. We identified a panel of genes with cancer specific epigenetic mediated aberrant expression. Two repressive histone modifications (H3K9m3 and H3K27m3) , cytosine methylation and gene expression were compared between normal human urothelial cell line (NHU) and malignant urothelial cells (EJ and RT112).

Species:

human

Samples:

3

Source:

E-GEOD-31864

Updated:

Dec.12, 2014

Registered:

Sep.16, 2014