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Home › Dataset Library › ApoD modulation mouse cerebellar transcriptome

Dataset: ApoD modulation mouse cerebellar transcriptome

The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-...

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The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat (PQ). However, the processes triggered by this up-regulation have not been explored. We present here a study of the effect of ApoD on the early transcriptional changes upon OS in the mouse cerebellum using microarray profiling. ApoD-KO and transgenic mice over-expressing ApoD in neurons are compared to wild-type controls.

Species:
mouse

Samples:
18

Source:
E-GEOD-28643

Updated:
Dec.12, 2014

Registered:
Nov.24, 2014


Factors: (via ArrayExpress)
Sample GENOTYPE
GSM709686 Wild type
GSM709686 Wild type
GSM709686 Wild type
GSM709689 ApoD knock-out
GSM709689 ApoD knock-out
GSM709689 ApoD knock-out
GSM709692 Human-ApoD transgenic gain of function mutant
GSM709692 Human-ApoD transgenic gain of function mutant
GSM709692 Human-ApoD transgenic gain of function mutant
GSM709695 wild-type
GSM709695 wild-type
GSM709695 wild-type
GSM709689 ApoD knock-out
GSM709689 ApoD knock-out
GSM709689 ApoD knock-out
GSM709692 Human-ApoD transgenic gain of function mutant
GSM709692 Human-ApoD transgenic gain of function mutant
GSM709692 Human-ApoD transgenic gain of function mutant

Tags

  • brain
  • cerebellum
  • nervous system

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