Dataset: ApoD modulation mouse cerebellar transcriptome
The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-...
The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat (PQ). However, the processes triggered by this up-regulation have not been explored. We present here a study of the effect of ApoD on the early transcriptional changes upon OS in the mouse cerebellum using microarray profiling. ApoD-KO and transgenic mice over-expressing ApoD in neurons are compared to wild-type controls.
- Species:
- mouse
- Samples:
- 18
- Source:
- E-GEOD-28643
- Updated:
- Dec.12, 2014
- Registered:
- Nov.24, 2014
Factors:
(via ArrayExpress)
| Sample | GENOTYPE |
|---|---|
| GSM709686 | Wild type |
| GSM709686 | Wild type |
| GSM709686 | Wild type |
| GSM709689 | ApoD knock-out |
| GSM709689 | ApoD knock-out |
| GSM709689 | ApoD knock-out |
| GSM709692 | Human-ApoD transgenic gain of function mutant |
| GSM709692 | Human-ApoD transgenic gain of function mutant |
| GSM709692 | Human-ApoD transgenic gain of function mutant |
| GSM709695 | wild-type |
| GSM709695 | wild-type |
| GSM709695 | wild-type |
| GSM709689 | ApoD knock-out |
| GSM709689 | ApoD knock-out |
| GSM709689 | ApoD knock-out |
| GSM709692 | Human-ApoD transgenic gain of function mutant |
| GSM709692 | Human-ApoD transgenic gain of function mutant |
| GSM709692 | Human-ApoD transgenic gain of function mutant |