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Home › Dataset Library › Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

Dataset: Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML...

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Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that originate from hematopoietic stem cells (HSC). The leukemia stem cell fraction in these two type of leukemias shared a common self-renewal pathway with normal hematopoietic stem cells. Keywords: Cell type comparison Total RNA from HSC (KLS), CMP, and GMP, and from leukemia stem cells (LGMP) was isolated and hybridized to Affymetrix expresison microarrays.

Species:
mouse

Samples:
15

Source:
E-GEOD-20377

Updated:
Dec.12, 2014

Registered:
Nov.24, 2014


Factors: (via ArrayExpress)
Sample CELL TYPE
GSM510377 HSC
GSM510377 HSC
GSM510377 HSC
GSM510380 CMP
GSM510380 CMP
GSM510380 CMP
GSM510383 GMP
GSM510383 GMP
GSM510383 GMP
GSM510386 LGMP derived from MLL-AF9 transduced GMP
GSM510386 LGMP derived from MLL-AF9 transduced GMP
GSM510386 LGMP derived from MLL-AF9 transduced GMP
GSM510389 LGMP derived from Hoxa9/Meis1a transduced GMP
GSM510389 LGMP derived from Hoxa9/Meis1a transduced GMP
GSM510389 LGMP derived from Hoxa9/Meis1a transduced GMP

Tags

  • cell
  • leukemia
  • stem cell

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