ArrayExpress Uploaderarrayexpress_sidmouseHSCHSCHSCCMPCMPCMPGMPGMPGMPLGMP derived from MLL-AF9 transduced GMPLGMP derived from MLL-AF9 transduced GMPLGMP derived from MLL-AF9 transduced GMPLGMP derived from Hoxa9/Meis1a transduced GMPLGMP derived from Hoxa9/Meis1a transduced GMPLGMP derived from Hoxa9/Meis1a transduced GMP846108Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML...E-GEOD-20377/profile/8773/arrayexpressuploader115cellleukemiastem cellDec.12, 2014FalseE-GEOD-20377_A-AFFY-36activation-or-maintenance-of-a-leukemia-stem-cellActivation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cellsNov.24, 2014Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that originate from hematopoietic stem cells (HSC). The leukemia stem cell fraction in these two type of leukemias shared a common self-renewal pathway with normal hematopoietic stem cells. Keywords: Cell type comparison Total RNA from HSC (KLS), CMP, and GMP, and from leukemia stem cells (LGMP) was isolated and hybridized to Affymetrix expresison microarrays.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20377http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20377/samples/