{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM510377": {"CELL TYPE": "HSC"}}, {"GSM510377": {"CELL TYPE": "HSC"}}, {"GSM510377": {"CELL TYPE": "HSC"}}, {"GSM510380": {"CELL TYPE": "CMP"}}, {"GSM510380": {"CELL TYPE": "CMP"}}, {"GSM510380": {"CELL TYPE": "CMP"}}, {"GSM510383": {"CELL TYPE": "GMP"}}, {"GSM510383": {"CELL TYPE": "GMP"}}, {"GSM510383": {"CELL TYPE": "GMP"}}, {"GSM510386": {"CELL TYPE": "LGMP derived from MLL-AF9 transduced GMP"}}, {"GSM510386": {"CELL TYPE": "LGMP derived from MLL-AF9 transduced GMP"}}, {"GSM510386": {"CELL TYPE": "LGMP derived from MLL-AF9 transduced GMP"}}, {"GSM510389": {"CELL TYPE": "LGMP derived from Hoxa9/Meis1a transduced GMP"}}, {"GSM510389": {"CELL TYPE": "LGMP derived from Hoxa9/Meis1a transduced GMP"}}, {"GSM510389": {"CELL TYPE": "LGMP derived from Hoxa9/Meis1a transduced GMP"}}], "id": 8461, "pop_total": 0, "platform": 8, "summary_wrapped": "Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML...", "geo_gse_id": "E-GEOD-20377", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 15, "tags": ["cell", "leukemia", "stem cell"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-20377_A-AFFY-36", "slug": "activation-or-maintenance-of-a-leukemia-stem-cell", "geo_gds_id": "", "name": "Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells", "created": "Nov.24, 2014", "summary": "Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that originate from hematopoietic stem cells (HSC). The leukemia stem cell fraction in these two type of leukemias shared a common self-renewal pathway with normal hematopoietic stem cells.  Keywords: Cell type comparison Total RNA from HSC (KLS), CMP, and GMP, and from leukemia stem cells (LGMP)  was isolated and hybridized to Affymetrix expresison microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20377", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20377/samples/"}