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Home › Dataset Library › Compounds profiling on MCF7

Dataset: Compounds profiling on MCF7

The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested...

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The effects of several compounds on the MCF7 human adenocarcinoma mammary cell line were analysed by gene expression profiling. Tested compounds: HSP90 inhibitors: 17AAG (Tanespimycin), NVP-AUY922, NMS-E973 (cpd developed at NMS). CDK inhibitors: CDK-887 (cpd developed at NMS). Topoisomerase inhibitors: Doxorubicin, SN38 (active metabolite of Irinotecan). The MCF7 cell line was treated with the different compounds for 6 hours at a dose equal to 5 times the IC50. Untreated MCF7 cells were used as a control. Two replicates per treatment.

Species:
human

Samples:
14

Source:
E-GEOD-19638

PubMed:
20679242

Updated:
Dec.12, 2014

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample TREATMENT
GSM490029 untreated
GSM490029 untreated
GSM49003 17AAG
GSM49003 17AAG
GSM490033 AUY922
GSM490033 AUY922
GSM490035 CDK-887
GSM490035 CDK-887
GSM490037 doxorubicin
GSM490037 doxorubicin
GSM490039 E973
GSM490039 E973
GSM49004 SN38
GSM49004 SN38

Tags

  • adenocarcinoma
  • cell
  • line

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