Dataset: Transcription profiling by array of human breast cancer cell line MDA-MB-231 with siRNa against Runx2, CBF-beta or a non-specific siRNA

[u'Cells of MDA-MB-231 breast cancer cell-line were transfected with siRNA against Runx2, CBF-beta or non-specific siRNA used as control. Runx2 is a member of the Runx transcription factor family and possesses a Runt domain capable of binding to the consensus DNA sequence ACC(A/G)CA. This domain also interacts with the co-activator protein core binding factor beta (CBF-beta), which enhances its binding to DNA. Runx2, primarily identified as a master regulator of bone development, but was also found expressed in the epithelium of the nascent mammary gland in mice. In contrast with its normal role in', {u'br': None}, {u'br': None}, u'breast, it has been shown that Runx2 is over-expressed in breast cancer cell lines.']

Species:

human

Samples:

10

Source:

E-MEXP-3230

PubMed:

22032690

Updated:

Dec.12, 2014

Registered:

Sep.22, 2014