Dataset: Transcription profiling by array of human HeLa cell line wild type and mutations C65S and 31-34A to investigate how APE1/Ref-1 protects cells from oxidative stress

APE1/Ref-1 protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through its independent activity as a redox transcriptional co-activator. To dissect between redox- and DNA-repair-mediated effects, here we performed transcription profiling of knock-in experiments using wild type and mutations C65S and 31-34A.

Species:

human

Samples:

9

Source:

E-MEXP-2941

PubMed:

21865600

Updated:

Dec.12, 2014

Registered:

Sep.22, 2014