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Home › Dataset Library › Transcription profiling of patients with four neurodegenerative disorders distinguishes tauopathies and identifies shared molecular pathways

Dataset: Transcription profiling of patients with four neurodegenerative disorders distinguishes tauopathies and identifies shared molecular pathways

We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with...

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We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with four neurodegenerative disorders (5 AD, 5 PSP, 5 PiD and 5 FTD patients) and 5 control subjects. All patients were matched for age, gender, ApoE-? and MAPT (tau) haplotype. From all groups a total of 790 probes were shown to be differently expressed when compared to control individuals. The results from these experiments were then used to investigate the correlations between clinical, pathological and molecular findings. From the 790 identified probes we extracted a gene set of 166 probes whose expression could discriminate between these disorders and normal ageing. This gene set can be further developed into an accurate microarray-based classification test. Furthermore, from this dataset we extracted a disease specific set of genes and identified two aging related transcription factors (FOXO1A and FOXO3A) as possible drug targets related to neurodegenerative disease.

Species:
human

Samples:
31

Source:
E-MEXP-2280

PubMed:
19714246

Updated:
Dec.12, 2014

Registered:
Sep.22, 2014


Factors: (via ArrayExpress)
Sample DISEASE_STAGE DISEASE_STATE
IB17 Constantinides type C1 Pick's disease
IB17 Constantinides type C1 Pick's disease
IB17 Constantinides type C1 Pick's disease
IB17 Constantinides type C1 Pick's disease
IB17 Constantinides type C1 Pick's disease
IB22 Constantinides type A Pick's disease
IB22 Constantinides type A Pick's disease
IB22 Constantinides type A Pick's disease
IB22 Constantinides type A Pick's disease
IB22 Constantinides type A Pick's disease
IB27 stage unknown Progressive supranuclear palsy
IB27 stage unknown Progressive supranuclear palsy
IB27 stage unknown Progressive supranuclear palsy
IB30 Braak stage 2 Progressive supranuclear palsy
IB27 stage unknown Progressive supranuclear palsy
IB32 Braak stage 6 Alzheimer's disease
IB32 Braak stage 6 Alzheimer's disease
IB32 Braak stage 6 Alzheimer's disease
IB32 Braak stage 6 Alzheimer's disease
IB32 Braak stage 6 Alzheimer's disease
IB37 Braak stage 1 normal
IB38 Braak stage 0 normal
IB37 Braak stage 1 normal
IB38 Braak stage 0 normal
IB37 Braak stage 1 normal
IB27 stage unknown Progressive supranuclear palsy
IB32 Braak stage 6 Alzheimer's disease
IB32 Braak stage 6 Alzheimer's disease
IB22 Constantinides type A Pick's disease
IB17 Constantinides type C1 Pick's disease
IB27 stage unknown Progressive supranuclear palsy

Tags

  • disease
  • genome
  • medial
  • neurodegenerative disease
  • pid
  • temporal lobe

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