ArrayExpress Uploaderarrayexpress_sid5143Constantinides type C1Pick's diseaseConstantinides type C1Pick's diseaseConstantinides type C1Pick's diseaseConstantinides type C1Pick's diseaseConstantinides type C1Pick's diseaseConstantinides type APick's diseaseConstantinides type APick's diseaseConstantinides type APick's diseaseConstantinides type APick's diseaseConstantinides type APick's diseasestage unknownProgressive supranuclear palsystage unknownProgressive supranuclear palsystage unknownProgressive supranuclear palsyBraak stage 2Progressive supranuclear palsystage unknownProgressive supranuclear palsyBraak stage 6Alzheimer's diseaseBraak stage 6Alzheimer's diseaseBraak stage 6Alzheimer's diseaseBraak stage 6Alzheimer's diseaseBraak stage 6Alzheimer's diseaseBraak stage 1normalBraak stage 0normalBraak stage 1normalBraak stage 0normalBraak stage 1normalstage unknownProgressive supranuclear palsyBraak stage 6Alzheimer's diseaseBraak stage 6Alzheimer's diseaseConstantinides type APick's diseaseConstantinides type C1Pick's diseasestage unknownProgressive supranuclear palsy04We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with...19714246E-MEXP-2280/profile/8773/arrayexpressuploader231diseasegenomemedialneurodegenerative diseasepidtemporal lobeDec.12, 2014FalseE-MEXP-2280_A-AFFY-44transcription-profiling-of-patients-with-four-neurTranscription profiling of patients with four neurodegenerative disorders distinguishes tauopathies and identifies shared molecular pathwaysSep.22, 2014We have constructed genome wide expression profiles from snap frozen post-mortem tissue from the medial temporal lobe of patients with four neurodegenerative disorders (5 AD, 5 PSP, 5 PiD and 5 FTD patients) and 5 control subjects. All patients were matched for age, gender, ApoE-? and MAPT (tau) haplotype. From all groups a total of 790 probes were shown to be differently expressed when compared to control individuals. The results from these experiments were then used to investigate the correlations between clinical, pathological and molecular findings. From the 790 identified probes we extracted a gene set of 166 probes whose expression could discriminate between these disorders and normal ageing. This gene set can be further developed into an accurate microarray-based classification test. Furthermore, from this dataset we extracted a disease specific set of genes and identified two aging related transcription factors (FOXO1A and FOXO3A) as possible drug targets related to neurodegenerative disease.http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2280humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-2280/samples/