Dataset: Transcription profiling by array of human liver after treatment with flucloxacillin

Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment with this antimicrobial. The genetic basis of susceptibility is poorly understood as is the underlying molecular mechanism for disease. There is some evidence that flucloxacillin is a pregnane X receptor (PXR) agonist. The current study was concerned with investigating the relevance of PXR to flucloxacillin toxicity and with the identification of genes changing in expression in response to flucloxacillin.

Species:

human

Samples:

24

Source:

E-MEXP-2128

Updated:

Dec.12, 2014

Registered:

Sep.22, 2014