Dataset: Transcription profiling of human monocyte-derived dendritic cells to study uptake of apoptotic cells by dendritci cells and induction of T-cell immunity

[u'The identification of molecules for apoptotic cells (AC) uptake by dendritic cells (DCs) and induction of T cell immunity is a major challenge in immunology.', {u'br': None}, u'DCs generated from monocytes in the presence of IFN-alpha (IFN-alpha-DCs) are competent in taking up ACs and inducing a strong T cell immunity. Capture of allogenetic apoptotic lymphocytes (APO-allo-PBLs) was associated with subcellular rearrangements of MHC class I/II molecules, subsequent cross-priming of auologous CD8+ T cells and CD4+ T cell activation. All these events were inhibited by the Scavenger Receptor (SR) LOX-1 protein, whose expression was up-regulated in IFN-alpha DCs. The results unravel a novel natural IFN-alpha-mediated pathway by which a defined SR molecule regulates AC uptake by DCs and subsequent induction of T cell immunity.']

Species:

human

Samples:

12

Source:

E-MEXP-2000

PubMed:

20009034

Updated:

Dec.12, 2014

Registered:

Jun.19, 2014