Dataset: Transcription profiling by array of human gastrointestinal stromal tumors with KIT mutations

GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However,...

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GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untreated GIST of the stomach and small intestine with GeneChip Human Genome U133 Plus 2.0 arrays. Experiment Overall Design: Total RNA was extracted from 32 fresh frozen tumour specimens. We analysed the global gene exprssion profiles of these GIST cases in order to clarify the genomic basis behind the malignant progression of this tumor

Species:: human
Samples:: 32
Source:: E-GEOD-8167
PubMed:: 18757323
Updated:: Dec.12, 2014
Registered:: Sep.22, 2014

Factors: (via ArrayExpress)

Sample	GENOTYPE	AGE	TUMOR SIZE	ORGANISM PART	SEX
GSE8167GSM202198	KIT mutation: wildtype	64	4	stomach	female
GSE8167GSM202209	KIT mutation: wildtype	50	21	stomach	male
GSE8167GSM202210	KIT mutation: Exon 11	51	12	stomach	male
GSE8167GSM202211	KIT mutation: Exon 11	71	6	stomach	male
GSE8167GSM202212	KIT mutation: Exon 11	63	13	stomach	female
GSE8167GSM202213	KIT mutation: Exon 11	52	7	stomach	male
GSE8167GSM202216	KIT mutation: Exon 11	81	6	stomach	male
GSE8167GSM202217	KIT mutation: Exon 11	41	4	stomach	female
GSE8167GSM202218	KIT mutation: wildtype	52	5	stomach	female
GSE8167GSM202220	KIT mutation: Exon 11	72	25	stomach	female
GSE8167GSM202221	KIT mutation: Exon 11	68	17	stomach	male
GSE8167GSM202198	KIT mutation: wildtype	64	4	stomach	female
GSE8167GSM202223	KIT mutation: wildtype	61	8	stomach	male
GSE8167GSM202225	KIT mutation: wildtype	69	7	stomach	male
GSE8167GSM202226	KIT mutation: Exon 11	47	4	stomach	male
GSE8167GSM202228	KIT mutation: Exon 11	71	11	stomach	male
GSE8167GSM202200	KIT mutation: Exon 11	68	19	stomach	male
GSE8167GSM202201	KIT mutation: Exon 11	54	10	stomach	male
GSE8167GSM202204	KIT mutation: Exon 11	56	38	stomach	male
GSE8167GSM202205	KIT mutation: Exon 11	40	10	stomach	female
GSE8167GSM202206	KIT mutation: Exon 11	58	13	stomach	male
GSE8167GSM202207	KIT mutation: wildtype	55	6	stomach	female
GSE8167GSM202208	KIT mutation: Exon 11	69	20	stomach	female
GSE8167GSM202197	KIT mutation: Exon 9	61	3	small intestine	female
GSE8167GSM202202	KIT mutation: Exon 9	68	4	small intestine	male
GSE8167GSM202203	KIT mutation: wildtype	77	4	small intestine	male
GSE8167GSM202214	KIT mutation: Exon 11	76	7	small intestine	male
GSE8167GSM202215	KIT mutation: Exon 11	34	18	small intestine	male
GSE8167GSM202219	KIT mutation: Exon 9	68	7	small intestine	male
GSE8167GSM202222	KIT mutation: Exon 9	82	4	small intestine	male
GSE8167GSM202224	KIT mutation: Exon 11	61	12	small intestine	female
GSE8167GSM202227	KIT mutation: wildtype	68	6	small intestine	female