Dataset: Transcription profiling by array of human gastrointestinal stromal tumors with KIT mutations

GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However,...

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GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untreated GIST of the stomach and small intestine with GeneChip Human Genome U133 Plus 2.0 arrays. Experiment Overall Design: Total RNA was extracted from 32 fresh frozen tumour specimens. We analysed the global gene exprssion profiles of these GIST cases in order to clarify the genomic basis behind the malignant progression of this tumor

Species:: human
Samples:: 32
Source:: E-GEOD-8167
PubMed:: 18757323
Updated:: Dec.12, 2014
Registered:: Sep.22, 2014

Factors: (via ArrayExpress)

Sample	AGE	ORGANISM PART	GENOTYPE	TUMOR SIZE	SEX
GSE8167GSM202198	64	stomach	KIT mutation: wildtype	4	female
GSE8167GSM202209	50	stomach	KIT mutation: wildtype	21	male
GSE8167GSM202210	51	stomach	KIT mutation: Exon 11	12	male
GSE8167GSM202211	71	stomach	KIT mutation: Exon 11	6	male
GSE8167GSM202212	63	stomach	KIT mutation: Exon 11	13	female
GSE8167GSM202213	52	stomach	KIT mutation: Exon 11	7	male
GSE8167GSM202216	81	stomach	KIT mutation: Exon 11	6	male
GSE8167GSM202217	41	stomach	KIT mutation: Exon 11	4	female
GSE8167GSM202218	52	stomach	KIT mutation: wildtype	5	female
GSE8167GSM202220	72	stomach	KIT mutation: Exon 11	25	female
GSE8167GSM202221	68	stomach	KIT mutation: Exon 11	17	male
GSE8167GSM202198	64	stomach	KIT mutation: wildtype	4	female
GSE8167GSM202223	61	stomach	KIT mutation: wildtype	8	male
GSE8167GSM202225	69	stomach	KIT mutation: wildtype	7	male
GSE8167GSM202226	47	stomach	KIT mutation: Exon 11	4	male
GSE8167GSM202228	71	stomach	KIT mutation: Exon 11	11	male
GSE8167GSM202200	68	stomach	KIT mutation: Exon 11	19	male
GSE8167GSM202201	54	stomach	KIT mutation: Exon 11	10	male
GSE8167GSM202204	56	stomach	KIT mutation: Exon 11	38	male
GSE8167GSM202205	40	stomach	KIT mutation: Exon 11	10	female
GSE8167GSM202206	58	stomach	KIT mutation: Exon 11	13	male
GSE8167GSM202207	55	stomach	KIT mutation: wildtype	6	female
GSE8167GSM202208	69	stomach	KIT mutation: Exon 11	20	female
GSE8167GSM202197	61	small intestine	KIT mutation: Exon 9	3	female
GSE8167GSM202202	68	small intestine	KIT mutation: Exon 9	4	male
GSE8167GSM202203	77	small intestine	KIT mutation: wildtype	4	male
GSE8167GSM202214	76	small intestine	KIT mutation: Exon 11	7	male
GSE8167GSM202215	34	small intestine	KIT mutation: Exon 11	18	male
GSE8167GSM202219	68	small intestine	KIT mutation: Exon 9	7	male
GSE8167GSM202222	82	small intestine	KIT mutation: Exon 9	4	male
GSE8167GSM202224	61	small intestine	KIT mutation: Exon 11	12	female
GSE8167GSM202227	68	small intestine	KIT mutation: wildtype	6	female