Dataset: Transcription profiling by array of human gastrointestinal stromal tumors with KIT mutations

GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However,...

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GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untreated GIST of the stomach and small intestine with GeneChip Human Genome U133 Plus 2.0 arrays. Experiment Overall Design: Total RNA was extracted from 32 fresh frozen tumour specimens. We analysed the global gene exprssion profiles of these GIST cases in order to clarify the genomic basis behind the malignant progression of this tumor

Species:: human
Samples:: 32
Source:: E-GEOD-8167
PubMed:: 18757323
Updated:: Dec.12, 2014
Registered:: Sep.22, 2014

Factors: (via ArrayExpress)

Sample	AGE	SEX	TUMOR SIZE	ORGANISM PART	GENOTYPE
GSE8167GSM202198	64	female	4	stomach	KIT mutation: wildtype
GSE8167GSM202209	50	male	21	stomach	KIT mutation: wildtype
GSE8167GSM202210	51	male	12	stomach	KIT mutation: Exon 11
GSE8167GSM202211	71	male	6	stomach	KIT mutation: Exon 11
GSE8167GSM202212	63	female	13	stomach	KIT mutation: Exon 11
GSE8167GSM202213	52	male	7	stomach	KIT mutation: Exon 11
GSE8167GSM202216	81	male	6	stomach	KIT mutation: Exon 11
GSE8167GSM202217	41	female	4	stomach	KIT mutation: Exon 11
GSE8167GSM202218	52	female	5	stomach	KIT mutation: wildtype
GSE8167GSM202220	72	female	25	stomach	KIT mutation: Exon 11
GSE8167GSM202221	68	male	17	stomach	KIT mutation: Exon 11
GSE8167GSM202198	64	female	4	stomach	KIT mutation: wildtype
GSE8167GSM202223	61	male	8	stomach	KIT mutation: wildtype
GSE8167GSM202225	69	male	7	stomach	KIT mutation: wildtype
GSE8167GSM202226	47	male	4	stomach	KIT mutation: Exon 11
GSE8167GSM202228	71	male	11	stomach	KIT mutation: Exon 11
GSE8167GSM202200	68	male	19	stomach	KIT mutation: Exon 11
GSE8167GSM202201	54	male	10	stomach	KIT mutation: Exon 11
GSE8167GSM202204	56	male	38	stomach	KIT mutation: Exon 11
GSE8167GSM202205	40	female	10	stomach	KIT mutation: Exon 11
GSE8167GSM202206	58	male	13	stomach	KIT mutation: Exon 11
GSE8167GSM202207	55	female	6	stomach	KIT mutation: wildtype
GSE8167GSM202208	69	female	20	stomach	KIT mutation: Exon 11
GSE8167GSM202197	61	female	3	small intestine	KIT mutation: Exon 9
GSE8167GSM202202	68	male	4	small intestine	KIT mutation: Exon 9
GSE8167GSM202203	77	male	4	small intestine	KIT mutation: wildtype
GSE8167GSM202214	76	male	7	small intestine	KIT mutation: Exon 11
GSE8167GSM202215	34	male	18	small intestine	KIT mutation: Exon 11
GSE8167GSM202219	68	male	7	small intestine	KIT mutation: Exon 9
GSE8167GSM202222	82	male	4	small intestine	KIT mutation: Exon 9
GSE8167GSM202224	61	female	12	small intestine	KIT mutation: Exon 11
GSE8167GSM202227	68	female	6	small intestine	KIT mutation: wildtype