Dataset: Transcription profiling by array of human gastrointestinal stromal tumors with KIT mutations

GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However,...

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GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untreated GIST of the stomach and small intestine with GeneChip Human Genome U133 Plus 2.0 arrays. Experiment Overall Design: Total RNA was extracted from 32 fresh frozen tumour specimens. We analysed the global gene exprssion profiles of these GIST cases in order to clarify the genomic basis behind the malignant progression of this tumor

Species:: human
Samples:: 32
Source:: E-GEOD-8167
PubMed:: 18757323
Updated:: Dec.12, 2014
Registered:: Sep.22, 2014

Factors: (via ArrayExpress)

Sample	TUMOR SIZE	AGE	GENOTYPE	ORGANISM PART	SEX
GSE8167GSM202198	4	64	KIT mutation: wildtype	stomach	female
GSE8167GSM202209	21	50	KIT mutation: wildtype	stomach	male
GSE8167GSM202210	12	51	KIT mutation: Exon 11	stomach	male
GSE8167GSM202211	6	71	KIT mutation: Exon 11	stomach	male
GSE8167GSM202212	13	63	KIT mutation: Exon 11	stomach	female
GSE8167GSM202213	7	52	KIT mutation: Exon 11	stomach	male
GSE8167GSM202216	6	81	KIT mutation: Exon 11	stomach	male
GSE8167GSM202217	4	41	KIT mutation: Exon 11	stomach	female
GSE8167GSM202218	5	52	KIT mutation: wildtype	stomach	female
GSE8167GSM202220	25	72	KIT mutation: Exon 11	stomach	female
GSE8167GSM202221	17	68	KIT mutation: Exon 11	stomach	male
GSE8167GSM202198	4	64	KIT mutation: wildtype	stomach	female
GSE8167GSM202223	8	61	KIT mutation: wildtype	stomach	male
GSE8167GSM202225	7	69	KIT mutation: wildtype	stomach	male
GSE8167GSM202226	4	47	KIT mutation: Exon 11	stomach	male
GSE8167GSM202228	11	71	KIT mutation: Exon 11	stomach	male
GSE8167GSM202200	19	68	KIT mutation: Exon 11	stomach	male
GSE8167GSM202201	10	54	KIT mutation: Exon 11	stomach	male
GSE8167GSM202204	38	56	KIT mutation: Exon 11	stomach	male
GSE8167GSM202205	10	40	KIT mutation: Exon 11	stomach	female
GSE8167GSM202206	13	58	KIT mutation: Exon 11	stomach	male
GSE8167GSM202207	6	55	KIT mutation: wildtype	stomach	female
GSE8167GSM202208	20	69	KIT mutation: Exon 11	stomach	female
GSE8167GSM202197	3	61	KIT mutation: Exon 9	small intestine	female
GSE8167GSM202202	4	68	KIT mutation: Exon 9	small intestine	male
GSE8167GSM202203	4	77	KIT mutation: wildtype	small intestine	male
GSE8167GSM202214	7	76	KIT mutation: Exon 11	small intestine	male
GSE8167GSM202215	18	34	KIT mutation: Exon 11	small intestine	male
GSE8167GSM202219	7	68	KIT mutation: Exon 9	small intestine	male
GSE8167GSM202222	4	82	KIT mutation: Exon 9	small intestine	male
GSE8167GSM202224	12	61	KIT mutation: Exon 11	small intestine	female
GSE8167GSM202227	6	68	KIT mutation: wildtype	small intestine	female