Dataset: Cyclosporine in patients with atopic dermatitis modulates activated inflammatory pathways and reverses epidermal pathology

After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical...

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After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical improvements were associated with significant gene expression changes in lesional but also nonlesional skin, particularly reductions in levels of TH2-, TH22-, and some TH17-related molecules (ie, IL-13, IL-22, CCL17, S100As, and elafin/peptidase inhibitor 3), and modulation of epidermal hyperplasia and differentiation measures. CsA's effects on AD skin pathology were evaluated by using gene expression and immunohistochemistry studies in baseline, week 2, and week 12 lesional and nonlesional biopsy specimens from 19 patients treated with 5 mg/kg/d CsA for 12 weeks.

Species:: human
Samples:: 109
Source:: E-GEOD-58558
Updated:: Dec.12, 2014
Registered:: Jul.10, 2014

Factors: (via ArrayExpress)

Sample	AGE	RESPONDER	SEX	LESIONS	SCORAD	TIME
GSM1414003	34	nonresponder	male	lesional	59	week 12
GSM1414002	34	nonresponder	male	non lesional	59	week 12
GSM141400	34	nonresponder	male	lesional	76	week 2
GSM1414000	34	nonresponder	male	non lesional	76	week 2
GSM1413999	34	nonresponder	male	lesional	76	day 1
GSM1413998	63	responder	male	lesional	16.1	week 12
GSM1413997	63	responder	male	lesional	58	week 2
GSM1413996	63	responder	male	lesional	98	day 1
GSM1413995	32	responder	male	lesional	25.5	week 12
GSM1413994	32	responder	male	non lesional	25.5	week 12
GSM1413993	32	responder	male	lesional	43.5	week 2
GSM1413992	32	responder	male	non lesional	43.5	week 2
GSM141399	32	responder	male	lesional	54	day 1
GSM1413990	32	responder	male	non lesional	54	day 1
GSM1413989	59	responder	male	lesional	39.5	week 12
GSM1413988	59	responder	male	non lesional	39.5	week 12
GSM1413987	59	responder	male	lesional	46.5	week 2
GSM1413986	59	responder	male	non lesional	46.5	week 2
GSM1413985	59	responder	male	lesional	97	day 1
GSM1413984	59	responder	male	non lesional	97	day 1
GSM1413983	32	responder	male	lesional	16	week 12
GSM1413982	32	responder	male	non lesional	16	week 12
GSM141398	32	responder	male	lesional	20	week 2
GSM1413980	32	responder	male	non lesional	20	week 2
GSM1413979	32	responder	male	lesional	74.5	day 1
GSM1413978	32	responder	male	non lesional	74.5	day 1
GSM1413977	18	nonresponder	male	lesional	37	week 12
GSM1413976	18	nonresponder	male	non lesional	37	week 12
GSM1413975	18	nonresponder	male	lesional	44.5	week 2
GSM1413974	18	nonresponder	male	non lesional	44.5	week 2
GSM1413973	18	nonresponder	male	lesional	73.5	day 1
GSM1413972	18	nonresponder	male	non lesional	73.5	day 1
GSM141397	33	responder	male	lesional	0	week 12
GSM1413970	33	responder	male	non lesional	0	week 12
GSM1413969	33	responder	male	lesional	5.9	week 2
GSM1413968	33	responder	male	non lesional	5.9	week 2
GSM1413967	33	responder	male	lesional	66	day 1
GSM1413966	33	responder	male	non lesional	66	day 1
GSM1413965	32	responder	male	lesional	27	week 12
GSM1413964	32	responder	male	non lesional	27	week 12
GSM1413963	32	responder	male	lesional	64.5	week 2
GSM1413962	32	responder	male	non lesional	64.5	week 2
GSM141396	32	responder	male	lesional	84.5	day 1
GSM1413960	32	responder	male	non lesional	84.5	day 1
GSM1413959	50	responder	female	lesional	7	week 12
GSM1413958	50	responder	female	non lesional	7	week 12
GSM1413957	69	responder	male	lesional	20	week 12
GSM1413956	69	responder	male	non lesional	20	week 12
GSM1413955	36	responder	female	lesional	18	week 12
GSM1413954	36	responder	female	non lesional	18	week 12
GSM1413953	42	responder	male	lesional	10	week 12
GSM1413952	42	responder	male	non lesional	10	week 12
GSM141395	42	responder	male	lesional	34	week 2
GSM1413950	42	responder	male	non lesional	34	week 2
GSM1413949	42	responder	male	lesional	53	day 1
GSM1413948	42	responder	male	non lesional	53	day 1
GSM1413947	36	responder	female	lesional	26	week 2
GSM1413946	36	responder	female	non lesional	26	week 2
GSM1413945	36	responder	female	lesional	65	day 1
GSM1413944	36	responder	female	non lesional	65	day 1
GSM1413943	69	responder	male	lesional	NA	week 2
GSM1413942	69	responder	male	non lesional	NA	week 2
GSM141394	69	responder	male	lesional	61	day 1
GSM1413940	69	responder	male	non lesional	61	day 1
GSM1413939	59	responder	female	lesional	6	week 12
GSM1413938	59	responder	female	non lesional	6	week 12
GSM1413937	59	responder	female	lesional	16	week 2
GSM1413936	59	responder	female	non lesional	16	week 2
GSM1413935	59	responder	female	lesional	56	day 1
GSM1413934	59	responder	female	non lesional	56	day 1
GSM1413933	40	responder	female	lesional	15	week 12
GSM1413932	40	responder	female	non lesional	15	week 12
GSM141393	40	responder	female	lesional	40	week 2
GSM1413930	40	responder	female	non lesional	40	week 2
GSM1413929	40	responder	female	lesional	72	day 1
GSM1413928	40	responder	female	non lesional	72	day 1
GSM1413927	67	responder	female	lesional	6	week 12
GSM1413926	67	responder	female	non lesional	6	week 12
GSM1413925	67	responder	female	lesional	14	week 2
GSM1413924	67	responder	female	non lesional	14	week 2
GSM1413923	67	responder	female	lesional	53	day 1
GSM1413922	67	responder	female	non lesional	53	day 1
GSM141392	50	responder	female	lesional	21	week 2
GSM1413920	50	responder	female	non lesional	21	week 2
GSM1413919	50	responder	female	non lesional	44	day 1
GSM1413918	59	responder	female	lesional	15	week 12
GSM1413917	59	responder	female	non lesional	15	week 12
GSM1413916	59	responder	female	lesional	NA	week 2
GSM1413915	59	responder	female	non lesional	NA	week 2
GSM1413914	59	responder	female	lesional	45	day 1
GSM1413913	59	responder	female	non lesional	45	day 1
GSM1413912	48	responder	male	lesional	7	week 12
GSM14139	48	responder	male	non lesional	7	week 12
GSM1413910	48	responder	male	lesional	18	week 2
GSM1413909	48	responder	male	non lesional	18	week 2
GSM1413908	48	responder	male	lesional	51	day 1
GSM1413907	48	responder	male	non lesional	51	day 1
GSM1413906	49	responder	female	lesional	8	week 12
GSM1413905	49	responder	female	non lesional	8	week 12
GSM1413904	49	responder	female	lesional	24	week 2
GSM1413903	49	responder	female	non lesional	24	week 2
GSM1413902	49	responder	female	lesional	56	day 1
GSM141390	49	responder	female	non lesional	56	day 1
GSM1413900	45	responder	male	lesional	8	week 12
GSM1413899	45	responder	male	non lesional	8	week 12
GSM1413898	45	responder	male	lesional	15	week 2
GSM1413897	45	responder	male	non lesional	15	week 2
GSM1413896	45	responder	male	lesional	56	day 1
GSM1413895	45	responder	male	non lesional	56	day 1