Dataset: Gene expression Profiling in Follicular Lymphomas
Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at...
Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been Follicular lymphoma (FL) is an indolent, but incurable subtype of non-Hodgkin lymphoma. These tumor harbor t (14;18) translocation in at least 90% of patients. Recently, activating EZH2 mutations have been found in a significant number of patients with FL. Gene expression profiling (GEP) was performed to determine differential gene-expression between the EZH2 mutated vs unmutated subgroups in FL. Total RNA extracted from fresh frozen specimens with FL diagnosis were processed for hybridization to Affymetrix HG-U133 plus 2 arrays. To enhance the identification of differential gene expression in FL tumor cells only, FL cases with a high B-cell content (enriched B-cell signature of >2-fold above the mean of the B-cell signature (pan B-cell markers) in the entire FL data set) were chosen for analysis.
- Species:
- human
- Samples:
- 69
- Source:
- E-GEOD-55267
- PubMed:
- 24634383
- Updated:
- Dec.12, 2014
- Registered:
- Jul.10, 2014
Sample | EZH2 MUTATION | AGE | FL GRADE | ORGANISM PART |
---|---|---|---|---|
GSM1333052 | WT | 49 | 3 | Follicular Lymphoma |
GSM133305 | WT | 55 | 3a | Follicular Lymphoma |
GSM1333050 | WT | 41 | 1 | Follicular Lymphoma |
GSM1333049 | WT | 40 | 3 | Follicular Lymphoma |
GSM1333048 | WT | 54 | 3 | Follicular Lymphoma |
GSM1333047 | WT | 64 | 3 | Follicular Lymphoma |
GSM1333046 | WT | 36 | 1 | Follicular Lymphoma |
GSM1333045 | WT | 54 | 2 | Follicular Lymphoma |
GSM1333044 | WT | 70 | 2 | Follicular Lymphoma |
GSM1333043 | WT | 58 | 3 | Follicular Lymphoma |
GSM1333042 | WT | NA | NA | Follicular Lymphoma |
GSM133304 | WT | 60 | 1 | Follicular Lymphoma |
GSM1333040 | WT | 38 | 3 | Follicular Lymphoma |
GSM1333039 | WT | 61 | 1 | Follicular Lymphoma |
GSM1333038 | WT | 48 | 1 | Follicular Lymphoma |
GSM1333037 | WT | 58 | 2 | Follicular Lymphoma |
GSM1333036 | WT | 53 | 1 | Follicular Lymphoma |
GSM1333035 | WT | 56 | 2 | Follicular Lymphoma |
GSM1333034 | WT | 44 | 2 | Follicular Lymphoma |
GSM1333033 | WT | 44 | 3 | Follicular Lymphoma |
GSM1333032 | WT | 46 | 1 | Follicular Lymphoma |
GSM1333042 | WT | NA | NA | Follicular Lymphoma |
GSM1333030 | WT | 55 | 2 | Follicular Lymphoma |
GSM1333029 | WT | 65 | 3 | Follicular Lymphoma |
GSM1333028 | WT | 58 | 1 | Follicular Lymphoma |
GSM1333027 | WT | 66 | 2 | Follicular Lymphoma |
GSM1333026 | WT | 69 | 2 | Follicular Lymphoma |
GSM1333049 | WT | 40 | 3 | Follicular Lymphoma |
GSM1333024 | WT | 70 | 3 | Follicular Lymphoma |
GSM1333049 | WT | 40 | 3 | Follicular Lymphoma |
GSM1333022 | WT | NA | not specified | Follicular Lymphoma |
GSM133302 | WT | 62 | 1 | Follicular Lymphoma |
GSM1333020 | NA | NA | NA | Na�ve_B cell |
GSM1333020 | NA | NA | NA | Na�ve_B cell |
GSM1333018 | NA | NA | NA | Centrocyte |
GSM1333018 | NA | NA | NA | Centrocyte |
GSM1333016 | NA | NA | NA | Centroblast |
GSM1333016 | NA | NA | NA | Centroblast |
GSM1333038 | WT | 48 | 1 | Follicular Lymphoma |
GSM1333013 | WT | 63 | 1 | Follicular Lymphoma |
GSM1333027 | WT | 66 | 2 | Follicular Lymphoma |
GSM13330 | WT | 47 | 2 | Follicular Lymphoma |
GSM1333010 | WT | 67 | 1 | Follicular Lymphoma |
GSM1333009 | WT | 51 | 1 | Follicular Lymphoma |
GSM1333008 | WT | 75 | 1 | Follicular Lymphoma |
GSM1333007 | WT | 69 | 3 | Follicular Lymphoma |
GSM1333032 | WT | 46 | 1 | Follicular Lymphoma |
GSM1333005 | WT | 80 | 2 | Follicular Lymphoma |
GSM1333027 | WT | 66 | 2 | Follicular Lymphoma |
GSM1333003 | WT | 35 | 2 | Follicular Lymphoma |
GSM1333002 | WT | 56 | 1 | Follicular Lymphoma |
GSM133300 | WT | 60 | 2 | Follicular Lymphoma |
GSM1333000 | WT | 60 | 3 | Follicular Lymphoma |
GSM1332999 | WT | NA | 2 | Follicular Lymphoma |
GSM1332998 | WT | 73 | 3 | Follicular Lymphoma |
GSM1332997 | WT | NA | 3a | Follicular Lymphoma |
GSM1332996 | WT | 69 | 3a | Follicular Lymphoma |
GSM1332995 | Y641S | 67 | NA | Follicular Lymphoma |
GSM1332994 | Y641S | 54 | 2 | Follicular Lymphoma |
GSM1332993 | Y641S | 71 | 1 | Follicular Lymphoma |
GSM1332992 | Y641N | 67 | 2 | Follicular Lymphoma |
GSM133299 | Y641H | 51 | 1 | Follicular Lymphoma |
GSM1332990 | Y641H | 67 | 1 | Follicular Lymphoma |
GSM1332989 | Y641F | 56 | 2 | Follicular Lymphoma |
GSM1332988 | Y641F | 45 | 2 | Follicular Lymphoma |
GSM1332987 | Y641F | NA | 2 | Follicular Lymphoma |
GSM1332986 | Y641F | 60 | 2 | Follicular Lymphoma |
GSM1332985 | Y641C | 84 | 3a | Follicular Lymphoma |
GSM1332984 | Y641C | 51 | 2 | Follicular Lymphoma |