Dataset: Transcription profiling of liver from farnesoid X receptor knockout mice
Expression profiling of whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte...
Expression profiling of whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte specific FXR KO mice (VFXR Cre+) on a C57BL/6J genetic background Whole body (WB) FXR knockout (KO) mice (FXR WB KO), liver-specific FXR KO mice (AFXR Cre+) and enterocyte specific FXR KO mice (VFXR Cre+) on a C57BL/6J genetic background were bred and maintained in the laboratory animal research facility at the University of Kansas Medical Center in rooms under a 12-hour light-dark cycle. All experiments used 10-16 week-old male mice. FXR was activated by treatment with the FXR synthetic agonist, GW4064, at 150 mg/kg. GW4064 or vehicle was administered by oral gavage at 6 p.m., followed by a second administration at 8 a.m. the next morning. Two hours later, the liver was harvested.
- Species:
- mouse
- Samples:
- 18
- Source:
- E-GEOD-54557
- Updated:
- Dec.12, 2014
- Registered:
- Nov.24, 2014
Sample | DOSE | GENOTYPE | TREATMENT |
---|---|---|---|
GSM1318788 | 0 mg/kg | Wildtype | Vehicle |
GSM1318788 | 0 mg/kg | Wildtype | Vehicle |
GSM1318788 | 0 mg/kg | Wildtype | Vehicle |
GSM131879 | 150 mg/kg | Wildtype | GW4064 |
GSM131879 | 150 mg/kg | Wildtype | GW4064 |
GSM131879 | 150 mg/kg | Wildtype | GW4064 |
GSM1318794 | 0 mg/kg | Liver Fxr KO | Vehicle |
GSM1318794 | 0 mg/kg | Liver Fxr KO | Vehicle |
GSM1318794 | 0 mg/kg | Liver Fxr KO | Vehicle |
GSM1318797 | 150 mg/kg | Liver Fxr KO | GW4064 |
GSM1318797 | 150 mg/kg | Liver Fxr KO | GW4064 |
GSM1318797 | 150 mg/kg | Liver Fxr KO | GW4064 |
GSM1318800 | 0 mg/kg | Whole body Fxr KO | Vehicle |
GSM1318800 | 0 mg/kg | Whole body Fxr KO | Vehicle |
GSM1318800 | 0 mg/kg | Whole body Fxr KO | Vehicle |
GSM1318803 | 150 mg/kg | Whole body Fxr KO | GW4064 |
GSM1318803 | 150 mg/kg | Whole body Fxr KO | GW4064 |
GSM1318803 | 150 mg/kg | Whole body Fxr KO | GW4064 |