Dataset: Global reprogramming of the cellular translational landscape facilitates cytomegalovirus replication
Genome-wide profiling establishes that human cytomegalovirus (HCMV) exerts an extensive, unforeseen level of specific control over which...
Genome-wide profiling establishes that human cytomegalovirus (HCMV) exerts an extensive, unforeseen level of specific control over which cellular mRNAs are recruited to or excluded from polyribosomes. The landscape of translationally-regulated host mRNAs regulates HCMV replication. The HCMV imposed translational signature shares similarities with cancer cells Two biological replicate experiments were performed profiling total and polysomal mRNAs from i) HCMV-infected vs mock-infected cells and ii) uninfected cells transduced with a lentivirus expressing doxycyclin (dox)-inducible HCMV UL38 +/- dox. Analysis of translationally-controlled host genes in HCMV-infected cell and cells expressing the HCMV UL38 gene product
- Species:
- human
- Samples:
- 16
- Source:
- E-GEOD-50938
- Updated:
- Dec.12, 2014
- Registered:
- Jul.11, 2014
| Sample | SAMPLE TYPE | TREATMENT |
|---|---|---|
| GSM1232770 | polysomal RNA | UL38 induced |
| GSM1232770 | polysomal RNA | UL38 induced |
| GSM1232768 | polysomal RNA | uninduced |
| GSM1232768 | polysomal RNA | uninduced |
| GSM1232766 | extracted total RNA | UL38 induced |
| GSM1232766 | extracted total RNA | UL38 induced |
| GSM1232764 | extracted total RNA | uninduced |
| GSM1232764 | extracted total RNA | uninduced |
| GSM1232762 | polysomal RNA | HCMV infected |
| GSM1232762 | polysomal RNA | HCMV infected |
| GSM1232760 | polysomal RNA | Mock infected |
| GSM1232760 | polysomal RNA | Mock infected |
| GSM1232758 | extracted total RNA | HCMV infected |
| GSM1232758 | extracted total RNA | HCMV infected |
| GSM1232756 | extracted total RNA | Mock infected |
| GSM1232756 | extracted total RNA | Mock infected |