Dataset: Expression changes in the absence of miR-128 in striatal D1-receptor positive neurons
MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron...
MicroRNA regulates protein expression of cells by repressing translation of specific target messenger transcripts. Loss of the neuron specific microRNA miR-128 in Dopamine D1-receptor expressing neurons in the murine striatum (D1-MSNs) lead to increased neuronal excitability, locomotor hyperactivity and fatal epilepsy. To examine expression changes in the absence of miR-128 in D1-MSNs, we used mice expressing EGFP-tagged ribosomes in D1-MSNs with either D1-MSN-specific homozygous deletion of miR-128-2 locus or no deletion. Transcripts co-immunoprecipitated with tagged ribosomes were analyzed by microarray. 9 mutant animals ( D1-MSN-tagged ribosome; D1-MSN specific miR-128-2 homozygous deletion) and 7 age matched littermate control animals (D1-MSN-tagged ribosome only).
- Species:
- mouse
- Samples:
- 16
- Source:
- E-GEOD-48813
- PubMed:
- 24311694
- Updated:
- Dec.12, 2014
- Registered:
- Nov.12, 2014
| Sample |
|---|
| GSM1185161 1 |
| GSM1185162 1 |
| GSM1185163 1 |
| GSM1185164 1 |
| GSM1185165 1 |
| GSM1185166 1 |
| GSM1185167 1 |
| GSM1185168 1 |
| GSM1185169 1 |
| GSM1185170 1 |
| GSM1185171 1 |
| GSM1185172 1 |
| GSM1185173 1 |
| GSM1185174 1 |
| GSM1185175 1 |
| GSM1185176 1 |