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Home › Dataset Library › Maternal obesity affects fetal neurodevelopmental and metabolic gene expression

Dataset: Maternal obesity affects fetal neurodevelopmental and metabolic gene expression

To investigate fetal gene expression in obese compared to lean women in the second trimester, by performing global gene expression...

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To investigate fetal gene expression in obese compared to lean women in the second trimester, by performing global gene expression analysis of amniotic fluid (AF) cell-free RNA Analysis of paired data from obese cases and lean controls revealed differential expression of 205 genes. Functional analysis of differentially expressed genes suggested down-regulation of apoptosis in fetuses of obese women, particularly within nervous system pathways involving the cerebral cortex, and activation of pro-estrogenic, pro-inflammatory transcriptional regulators. Prospective whole transcriptome microarray study analyzing cell-free RNA in AF from obese cases and lean controls in the second trimester. Significantly differentially-regulated genes in fetuses of obese cases (N= 8) vs. matched lean controls (N = 8) were identified and functional analyses were performed. Tissue-specific differential gene expression in fetuses of obese women was also examined.

Species:
human

Samples:
16

Source:
E-GEOD-48521

Updated:
Dec.12, 2014

Registered:
Jul.12, 2014


Factors: (via ArrayExpress)
Sample MATERNAL BMI GESTATIONAL AGE FETAL SEX
GSM1180240 21.8 17+4 male
GSM1180239 22.7 18+4 female
GSM1180238 22.7 20+4 female
GSM1180237 20.7 18+6 male
GSM1180236 24 17+1 male
GSM1180235 23.6 18+0 female
GSM1180234 21.3 16+1 male
GSM1180233 18.9 16+5 female
GSM1180232 39.5 17+6 male
GSM118023 34.5 19+5 female
GSM1180230 33 20+1 female
GSM1180229 36.3 17+5 male
GSM1180228 30.4 16+0 male
GSM1180227 39.6 19+2 female
GSM1180226 33 16+2 male
GSM1180225 33.7 15+6 female

Tags

  • cell
  • cerebral cortex
  • cortex
  • nervous system

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