Dataset: A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation

OSCC is associated with substantial mortality and morbidity. In this study, we built on our previous molecular work to identify and...

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OSCC is associated with substantial mortality and morbidity. In this study, we built on our previous molecular work to identify and validate a prognostic 13-gene signature that showed a higher ability than tumor stage in predicting survival for patients with HPV-negative oral squamous cell carcinoma (OSCC). We previously reported 131 genes to be associated with survival in OSCC patients. In this study, we applied L1/L2-penalized Cox regression models to the Affymetrix array data from 97 HPV-negative OSCC patients on the 131 gene to identify a model for prediction of OSCC-specific survival. We then tested the model in an independent dataset and compared to tumor stage.

Species:: human
Samples:: 97
Source:: E-GEOD-41613
PubMed:: 23319825
Updated:: Dec.12, 2014
Registered:: Jul.12, 2014

Factors: (via ArrayExpress)

Sample	AGE	TUMOR STAGE	SEX	VITAL	TREATMENT	FU TIME
GSM1020195	60-88	I/II	male	alive	uni-modality	52.60
GSM1020194	60-88	I/II	female	alive	uni-modality	53.88
GSM1020193	60-88	I/II	female	alive	uni-modality	54.41
GSM1020192	40-49	I/II	male	alive	uni-modality	54.57
GSM102019	19-39	III/IV	female	Dead-oral ca	multii-modality	8.38
GSM1020190	50-59	III/IV	male	Dead -unk cause	multii-modality	20.01
GSM1020189	60-88	I/II	male	alive	uni-modality	55.10
GSM1020188	60-88	I/II	male	alive	multii-modality	56.02
GSM1020187	60-88	III/IV	male	Dead-non OC	uni-modality	0.46
GSM1020186	40-49	I/II	male	alive	uni-modality	57.53
GSM1020185	60-88	III/IV	male	Dead-oral ca	multii-modality	6.54
GSM1020184	50-59	I/II	male	Dead-non OC	multii-modality	14.42
GSM1020183	60-88	I/II	male	Dead-non OC	uni-modality	35.38
GSM1020182	50-59	III/IV	male	Dead-non OC	multii-modality	17.02
GSM102018	50-59	III/IV	male	Dead-non OC	multii-modality	45.93
GSM1020180	40-49	III/IV	male	alive	multii-modality	57.63
GSM1020179	60-88	I/II	male	alive	uni-modality	62.85
GSM1020178	60-88	III/IV	female	Dead-non OC	uni-modality	1.22
GSM1020177	60-88	I/II	female	alive	uni-modality	58.71
GSM1020176	60-88	III/IV	male	Dead-oral ca	multii-modality	6.90
GSM1020175	50-59	I/II	male	alive	uni-modality	59.24
GSM1020174	40-49	III/IV	male	Dead-oral ca	multii-modality	9.23
GSM1020173	60-88	I/II	male	Dead-oral ca	uni-modality	9.86
GSM1020172	60-88	I/II	female	alive	multii-modality	59.96
GSM102017	60-88	III/IV	male	alive	multii-modality	60.65
GSM1020170	60-88	I/II	male	alive	uni-modality	61.01
GSM1020169	50-59	III/IV	male	alive	multii-modality	59.47
GSM1020168	40-49	III/IV	male	alive	multii-modality	61.08
GSM1020167	50-59	III/IV	female	Dead -unk cause	multii-modality	51.61
GSM1020166	60-88	I/II	male	alive	uni-modality	61.73
GSM1020165	60-88	III/IV	male	Dead-oral ca	uni-modality	19.12
GSM1020164	60-88	III/IV	male	alive	multii-modality	61.54
GSM1020163	60-88	III/IV	male	alive	uni-modality	60.55
GSM1020162	60-88	III/IV	female	Dead-oral ca	multii-modality	35.12
GSM102016	50-59	I/II	male	alive	uni-modality	63.38
GSM1020160	60-88	I/II	male	alive	uni-modality	63.54
GSM1020159	40-49	III/IV	female	alive	multii-modality	65.45
GSM1020158	50-59	III/IV	male	Dead-oral ca	multii-modality	10.68
GSM1020157	60-88	III/IV	male	Dead-oral ca	uni-modality	2.40
GSM1020156	60-88	I/II	male	alive	uni-modality	65.22
GSM1020155	19-39	I/II	male	alive	uni-modality	66.56
GSM1020154	50-59	I/II	male	alive	multii-modality	66.60
GSM1020153	19-39	III/IV	male	alive	multii-modality	67.55
GSM1020152	50-59	I/II	male	Dead-non OC	uni-modality	19.65
GSM102015	60-88	I/II	female	alive	uni-modality	67.94
GSM1020150	60-88	III/IV	male	alive	multii-modality	68.14
GSM1020149	50-59	I/II	female	alive	multii-modality	70.08
GSM1020148	19-39	I/II	female	alive	uni-modality	70.08
GSM1020147	50-59	I/II	female	alive	uni-modality	69.16
GSM1020146	60-88	III/IV	female	Dead-oral ca	multii-modality	6.44
GSM1020145	60-88	III/IV	male	Dead-oral ca	multii-modality	12.29
GSM1020144	60-88	III/IV	female	alive	multii-modality	68.47
GSM1020143	50-59	I/II	male	Dead -unk cause	uni-modality	64.99
GSM1020142	50-59	III/IV	male	alive	multii-modality	73.26
GSM102014	60-88	III/IV	male	alive	multii-modality	72.28
GSM1020140	60-88	I/II	male	alive	uni-modality	73.17
GSM1020139	19-39	III/IV	male	Dead-oral ca	multii-modality	14.75
GSM1020138	50-59	I/II	female	alive	uni-modality	74.64
GSM1020137	60-88	III/IV	male	Dead-non OC	multii-modality	43.24
GSM1020136	60-88	I/II	male	alive	uni-modality	75.07
GSM1020135	50-59	III/IV	female	Dead-non OC	multii-modality	26.81
GSM1020134	40-49	I/II	male	Dead-oral ca	multii-modality	29.14
GSM1020133	60-88	I/II	male	alive	multii-modality	76.85
GSM1020132	50-59	III/IV	male	Dead-oral ca	multii-modality	20.11
GSM102013	60-88	III/IV	female	Dead-oral ca	multii-modality	24.87
GSM1020130	60-88	III/IV	male	Dead-oral ca	unknown	3.52
GSM1020129	60-88	III/IV	female	Dead -unk cause	multii-modality	76.75
GSM1020128	50-59	III/IV	female	Dead-non OC	uni-modality	41.17
GSM1020127	60-88	III/IV	male	alive	multii-modality	78.95
GSM1020126	60-88	I/II	female	Dead -unk cause	uni-modality	35.45
GSM1020125	19-39	III/IV	female	Dead-oral ca	multii-modality	5.85
GSM1020124	60-88	III/IV	female	Dead-oral ca	multii-modality	24.25
GSM1020123	40-49	III/IV	male	Dead-oral ca	uni-modality	21.78
GSM1020122	50-59	I/II	female	Dead-non OC	multii-modality	18.40
GSM102012	40-49	III/IV	female	Dead-oral ca	multii-modality	15.41
GSM1020120	40-49	I/II	male	alive	uni-modality	80.79
GSM1020119	50-59	III/IV	male	alive	multii-modality	80.16
GSM1020118	40-49	III/IV	female	Dead-oral ca	uni-modality	15.31
GSM1020117	50-59	III/IV	male	Dead -unk cause	uni-modality	9.92
GSM1020116	40-49	III/IV	male	Dead -unk cause	multii-modality	78.29
GSM1020115	50-59	III/IV	male	Dead-non OC	multii-modality	66.63
GSM1020114	60-88	I/II	male	Dead-oral ca	uni-modality	7.23
GSM1020113	50-59	III/IV	male	Dead-oral ca	multii-modality	7.16
GSM1020112	60-88	I/II	male	alive	uni-modality	81.51
GSM1020	50-59	III/IV	male	Dead-non OC	uni-modality	28.52
GSM1020110	40-49	III/IV	male	Dead-oral ca	multii-modality	10.05
GSM1020109	60-88	III/IV	male	Dead-oral ca	multii-modality	14.16
GSM1020108	60-88	III/IV	female	alive	multii-modality	82.92
GSM1020107	50-59	III/IV	male	Dead-oral ca	multii-modality	46.88
GSM1020106	60-88	I/II	female	alive	uni-modality	84.24
GSM1020105	60-88	III/IV	female	Dead-oral ca	multii-modality	40.71
GSM1020104	40-49	III/IV	female	alive	multii-modality	85.03
GSM1020103	40-49	I/II	male	Dead-oral ca	uni-modality	28.62
GSM1020102	60-88	III/IV	male	Dead-non OC	multii-modality	3.38
GSM102010	50-59	III/IV	male	Dead-oral ca	multii-modality	6.54
GSM1020100	50-59	I/II	male	Dead-oral ca	uni-modality	55.66
GSM1020099	40-49	I/II	female	alive	uni-modality	62.85