Dataset: EZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations
This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant...
This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines GSE40971: Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor GSE41239: Gene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2 Refer to individual Series
- Species:
- human
- Samples:
- 46
- Source:
- E-GEOD-40972
- PubMed:
- 23051747
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
Factors:
(via ArrayExpress)
| Sample | AVERAGE GIC50 | CELL LINE | TREATMENT | VARIATION | CHIP ANTIBODY |
|---|---|---|---|---|---|
| GSM1006157 | 28 nM | Pfeiffer | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006157 | 28 nM | Pfeiffer | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006159 | 28 nM | Pfeiffer | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006159 | 28 nM | Pfeiffer | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM100616 | 134 nM nM | WSU-DLCL2 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006162 | 134 nM | WSU-DLCL2 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006163 | 134 nM | WSU-DLCL2 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006163 | 134 nM | WSU-DLCL2 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006165 | 232 nM | KARPAS-422 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006165 | 232 nM | KARPAS-422 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006167 | 232 nM | KARPAS-422 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006167 | 232 nM | KARPAS-422 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006169 | 448 nM | SU-DHL-10 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006169 | 448 nM | SU-DHL-10 | DMSO (72h) | EZH2 mutant | not specified |
| GSM100617 | 448 nM | SU-DHL-10 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM100617 | 448 nM | SU-DHL-10 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006173 | 516 nM | Ht | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006173 | 516 nM | Ht | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006175 | 516 nM | Ht | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1006175 | 516 nM | Ht | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1006177 | 582 nM | SU-DHL-6 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006177 | 582 nM | SU-DHL-6 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006179 | 582 nM | SU-DHL-6 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006179 | 582 nM | SU-DHL-6 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM100618 | 861 nM | DB | DMSO (72h) | EZH2 mutant | not specified |
| GSM100618 | 861 nM | DB | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006183 | 861 nM | DB | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006183 | 861 nM | DB | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006185 | 1019 nM | OCI-LY-19 | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006185 | 1019 nM | OCI-LY-19 | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006187 | 1019 nM | OCI-LY-19 | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1006187 | 1019 nM | OCI-LY-19 | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1006189 | not specified | SU-DHL-4 | DMSO (72h) | EZH2 mutant | not specified |
| GSM1006189 | not specified | SU-DHL-4 | DMSO (72h) | EZH2 mutant | not specified |
| GSM100619 | not specified | SU-DHL-4 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM100619 | not specified | SU-DHL-4 | GSK126 (500nM; 72h) | EZH2 mutant | not specified |
| GSM1006193 | 13786 nM | Toledo | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006193 | 13786 nM | Toledo | DMSO (72h) | EZH2 wild type | not specified |
| GSM1006195 | 13786 nM | Toledo | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1006195 | 13786 nM | Toledo | GSK126 (500nM; 72h) | EZH2 wild type | not specified |
| GSM1012074 | not specified | KARPAS-422 | Non targetting Control (10days) | not specified | not specified |
| GSM1012075 | not specified | KARPAS-422 | shEZH2 (10days) | not specified | not specified |
| GSM1012074 | not specified | KARPAS-422 | Non targetting Control (10days) | not specified | not specified |
| GSM1012075 | not specified | KARPAS-422 | shEZH2 (10days) | not specified | not specified |
| GSM1012078 | not specified | Pfeiffer | Non targetting Control (10days) | not specified | not specified |
| GSM1012079 | not specified | Pfeiffer | shEZH2 (10days) | not specified | not specified |