Dataset: IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines...
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of melanogenesis pathway Comparison of one batch of primary human melanocyte line cultured in serum free media, treated with TNF and/or IL-17, for either 24 or 48 hours.
- Species:
- human
- Samples:
- 12
- Source:
- E-GEOD-40413
- Updated:
- Dec.12, 2014
- Registered:
- Jul.12, 2014
Factors:
(via ArrayExpress)
| Sample | TREATMENT | TIME |
|---|---|---|
| GSM993410 | TNF (10ng/mL)+IL-17 (200ng/mL) | 48 hour cyotkine treatment |
| GSM993409 | TNF (10ng/mL)+IL-17 (20ng/mL) | 48 hour cyotkine treatment |
| GSM993408 | IL-17 (200ng/mL) | 48 hour cyotkine treatment |
| GSM993407 | IL-17 (20ng/mL) | 48 hour cyotkine treatment |
| GSM993406 | TNF (10ng/mL) | 48 hour cyotkine treatment |
| GSM993405 | Ctrl | 48 hour cyotkine treatment |
| GSM993404 | TNF (10ng/mL)+IL-17 (200ng/mL) | 24 hour cytokine treatment |
| GSM993403 | TNF (10ng/mL)+IL-17 (20ng/mL) | 24 hour cytokine treatment |
| GSM993402 | IL-17 (200ng/mL) | 24 hour cytokine treatment |
| GSM99340 | IL-17 (20ng/mL) | 24 hour cytokine treatment |
| GSM993400 | TNF (10ng/mL) | 24 hour cytokine treatment |
| GSM993399 | Ctrl | 24 hour cytokine treatment |