Dataset: Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting
Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism,...
Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated transcriptional profiling analyses to study the dynamics and functional implications of endoplasmic reticulum (ER)-associated protein synthesis in the mouse liver under conditions of obesity and nutrient deprivation. lean wild type and genetically obese (ob/ob) mice with or without overnight fasting were sacrificed with their liver tissues removed. ER-associated polysomes were purified and analyzed by microarray.
- Species:
- mouse
- Samples:
- 10
- Source:
- E-GEOD-39375
- Updated:
- Dec.12, 2014
- Registered:
- Nov.12, 2014
| Sample | GENOTYPE | DIET |
|---|---|---|
| GSM967008 | ob/ob | overnight fasted, Diet 5058 |
| GSM967009 | wild type | overnight fasted, Diet 5058 |
| GSM967010 | ob/ob | ad libitum fed, Diet 5058 |
| GSM9670 | wild type | ad libitum fed, Diet 5058 |
| GSM967010 | ob/ob | ad libitum fed, Diet 5058 |
| GSM9670 | wild type | ad libitum fed, Diet 5058 |
| GSM967010 | ob/ob | ad libitum fed, Diet 5058 |
| GSM9670 | wild type | ad libitum fed, Diet 5058 |
| GSM967008 | ob/ob | overnight fasted, Diet 5058 |
| GSM967009 | wild type | overnight fasted, Diet 5058 |