Dataset: Expression data from intestinal mucosa of patients with UC
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with preiods of active disease followed by remission. We performed...
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with preiods of active disease followed by remission. We performed a whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, as well as non-inflammatory controls. Ulcerative colitis patients and non-inflammatory controls were collected for RNA extraction and hybridization on Affymetrix microarrays. Inclusion criteria for UC patients were: age between 18 and 65, diagnosis of UC established at least 6 months before inclusion and exclusion of concomitant infection. Active disease was defined by endoscopic and histologic score: Mayo sub score >=2 and MATTS >=3 respectively . Inactive disease was also defined by endoscopic and histologic score: Mayo sub score =0 and MATTS <=2 respectively, and a remission state for a minimum of 5 month prior to biopsy collection, and remained inactive for at least 6 months after. Uninvolved mucosa from patients with active UC was defined as a colonic segment with completely normal endoscopic appearance, normal histology, and absence of any previous evidence of active disease. Finally, a total of 43 biopsies were analyzed: 13 healthy controls, 8 inactive UC, 7 non-involved active UC and 15 involved active UC.
- Species:
- human
- Samples:
- 43
- Source:
- E-GEOD-38713
- PubMed:
- 23135761
- Updated:
- Dec.12, 2014
- Registered:
- Jul.12, 2014
| Sample | DISEASE EXTENSION | AGE YEARS | EVOLUTION TIME YEARS | TREATMENT | SEX |
|---|---|---|---|---|---|
| GSM948592 | Left-sided colitis | 46 | not specified | azathioprine | female |
| GSM94859 | Pancolitis | 51 | 2 | azathioprine | male |
| GSM948590 | Pancolitis | 62 | 4 | azathioprine | female |
| GSM948589 | Pancolitis | 34 | 14 | azathioprine | female |
| GSM948588 | Pancolitis | 41 | 15 | 5-ASA | female |
| GSM948587 | Pancolitis | 30 | 3 | Systemic steroids | female |
| GSM948586 | Left-sided colitis | 36 | not specified | No treatment | female |
| GSM948585 | Left-sided colitis | 58 | 10 | No treatment | male |
| GSM948584 | Pancolitis | 43 | 7 | azathioprine | female |
| GSM948584 | Pancolitis | 43 | 7 | azathioprine | female |
| GSM948582 | Pancolitis | 34 | 13 | 5-ASA | female |
| GSM948582 | Pancolitis | 34 | 13 | 5-ASA | female |
| GSM948580 | Left-sided colitis | 47 | 1 | azathioprine | female |
| GSM948580 | Left-sided colitis | 47 | 1 | azathioprine | female |
| GSM948578 | Left-sided colitis | 41 | 7 | 5-ASA | female |
| GSM948578 | Left-sided colitis | 41 | 7 | 5-ASA | female |
| GSM948576 | Left-sided colitis | 39 | 3 | azathioprine | male |
| GSM948576 | Left-sided colitis | 39 | 3 | azathioprine | male |
| GSM948574 | Left-sided colitis | 34 | 7 | azathioprine | male |
| GSM948574 | Left-sided colitis | 34 | 7 | azathioprine | male |
| GSM948572 | Left-sided colitis | 40 | 13 | 5-ASA | female |
| GSM948572 | Left-sided colitis | 40 | 13 | 5-ASA | female |
| GSM948570 | Pancolitis | 60 | 29 | 5-ASA | female |
| GSM948569 | Left-sided colitis | 36 | 3 | azathioprine | female |
| GSM948568 | Left-sided colitis | 33 | 8 | 5-ASA | male |
| GSM948567 | Left-sided colitis | 63 | 10 | 5-ASA | female |
| GSM948566 | Left-sided colitis | 53 | 8 | 5-ASA | male |
| GSM948565 | Left-sided colitis | 60 | 22 | 5-ASA | female |
| GSM948564 | Pancolitis | 50 | 6 | azathioprine | male |
| GSM948563 | Left-sided colitis | 40 | 13 | azathioprine | female |
| GSM948562 | -- | 50 | -- | -- | female |
| GSM94856 | -- | 40 | -- | -- | male |
| GSM948560 | -- | 50 | -- | -- | male |
| GSM948559 | -- | 38 | -- | -- | female |
| GSM948558 | -- | 22 | -- | -- | female |
| GSM948557 | -- | 54 | -- | -- | female |
| GSM948556 | -- | 36 | -- | -- | female |
| GSM948555 | -- | 55 | -- | -- | female |
| GSM948554 | -- | 60 | -- | -- | female |
| GSM948553 | -- | 45 | -- | -- | female |
| GSM948552 | -- | 41 | -- | -- | male |
| GSM94855 | -- | 30 | -- | -- | male |
| GSM948550 | -- | 20 | -- | -- | male |