Dataset: Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Human and Mice
Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of...
Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of histologically characterized multiple sclerosis (MS) brain lesions in comparison with control brain samples to identify differentially expressed molecules. We identified CD47 as a target of interest and studied its biology in MS and EAE. We isolated total RNA from acute plaque (AP), chronic active plaque (CAP) and chronic plaque (CP) from MS brains and white matter from healthy controls and performed microarray studies.
- Species:
- human
- Samples:
- 7
- Source:
- E-GEOD-38010
- PubMed:
- 24475162
- Updated:
- Dec.12, 2014
- Registered:
- Sep.19, 2014
Factors:
(via ArrayExpress)
| Sample | DISEASE STATE | HISTOLOGY | ORGANISM PART |
|---|---|---|---|
| GSM931812 | healthy control | control | brain white matter |
| GSM931812 | healthy control | control | brain white matter |
| GSM931814 | multiple sclerosis early stage-active inflammation | active plaque | multiple sclerosis brain lesion |
| GSM931815 | multiple sclerosis following demyelination-active inflammation | chronice active plaque | multiple sclerosis brain lesion |
| GSM931815 | multiple sclerosis following demyelination-active inflammation | chronice active plaque | multiple sclerosis brain lesion |
| GSM931817 | multiple sclerosis after inflammation has subsided-late stage | chronic plaque | multiple sclerosis brain lesion |
| GSM931817 | multiple sclerosis after inflammation has subsided-late stage | chronic plaque | multiple sclerosis brain lesion |