Dataset: HER2-enriched tumor initiating cell (HTIC) genomic predictor of response following neoadjuvant trastuzumab-based chemotherapy in HER2+ breast cancer

We identified a 17-gene Her2-enriched tumor initiating cell (HTIC) signature in MMTV-Her2/Neu mouse mammary TICs. Here, we show that...

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We identified a 17-gene Her2-enriched tumor initiating cell (HTIC) signature in MMTV-Her2/Neu mouse mammary TICs. Here, we show that patients with HTICS+ HER2+:ERα− tumors are more likely to achieve a pathologic complete response to trastuzumab-based neoadjuvant chemotherapy compared with HER2+:ER+ tumors. Neoadjuvant study of 50 HER2-positive breast cancer cases treated with trastuzumab-based chemotherapy pre-operatively. Pre-treatment FNA from primary tumors were obtained and RNA extracted and hybridized to Affymetrix microarrays according to manufacturer protocol. Pathologic response was assessed at the end of neoadjuvant treatment.

Species:: human
Samples:: 50
Source:: E-GEOD-37946
Updated:: Dec.12, 2014
Registered:: Jun.18, 2014

Factors: (via ArrayExpress)

Sample	PR	AGE	STAGE	RESPONSE	ER
GSM930574	NEG	49	IV	RD	NEG
GSM930573	POS	62	IIIC	RD	POS
GSM930572	POS	24	IIIC	RD	POS
GSM93057	NEG	54	IIIC	RD	NEG
GSM930570	POS	72	IIB	RD	POS
GSM930569	NEG	55	IIIC	RD	NEG
GSM930568	NEG	61	IIIC	RD	NEG
GSM930567	POS	48	IIIA	RD	POS
GSM930566	NEG	39	IIIC	RD	NEG
GSM930565	NEG	50	IIIA	RD	POS
GSM930564	NEG	44	IIA	RD	NEG
GSM930563	NEG	51	IIB	RD	NEG
GSM930562	NEG	61	IIB	RD	POS
GSM93056	NEG	30	IIIB	RD	NEG
GSM930560	NEG	52	IIIA	RD	NEG
GSM930559	NEG	69	IIA	RD	NEG
GSM930558	NEG	56	IIIC	RD	POS
GSM930557	NEG	73	IIA	RD	NEG
GSM930556	POS	47	IIIC	RD	POS
GSM930555	NEG	41	IIIC	RD	NEG
GSM930554	POS	49	IIA	RD	POS
GSM930553	POS	28	IIIB	RD	POS
GSM930552	NEG	57	IIA	RD	NEG
GSM93055	NEG	46	IIIC	PCR	NEG
GSM930550	POS	30	not specified	PCR	POS
GSM930549	NEG	65	IIB	PCR	NEG
GSM930548	POS	52	IIIB	PCR	POS
GSM930547	NEG	56	IIB	PCR	NEG
GSM93055	NEG	46	IIIC	PCR	NEG
GSM930545	POS	56	IIIA	PCR	POS
GSM930544	NEG	53	IIB	PCR	NEG
GSM930543	NEG	62	IIIC	PCR	NEG
GSM930542	NEG	55	IIA	PCR	NEG
GSM93054	NEG	51	IIIB	PCR	NEG
GSM930540	POS	53	IIIA	PCR	POS
GSM930539	NEG	41	IIIC	PCR	NEG
GSM930538	NEG	50	IIIA	PCR	POS
GSM930537	NEG	63	IIA	PCR	POS
GSM930536	NEG	38	I	PCR	POS
GSM930535	NEG	43	IIIA	PCR	NEG
GSM930534	NEG	51	IIIC	PCR	NEG
GSM930533	NEG	45	IIIC	PCR	NEG
GSM930532	POS	56	IIIA	PCR	NEG
GSM93053	NEG	47	IIA	PCR	NEG
GSM930530	NEG	36	I	PCR	NEG
GSM930529	POS	38	IIA	PCR	POS
GSM930528	NEG	30	IIIA	PCR	NEG
GSM930527	NEG	52	IIIB	PCR	NEG
GSM930526	NEG	34	IIA	PCR	NEG
GSM930525	NEG	50	IIA	PCR	NEG