Dataset: HER2-enriched tumor initiating cell (HTIC) genomic predictor of response following neoadjuvant trastuzumab-based chemotherapy in HER2+ breast cancer

We identified a 17-gene Her2-enriched tumor initiating cell (HTIC) signature in MMTV-Her2/Neu mouse mammary TICs. Here, we show that...

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We identified a 17-gene Her2-enriched tumor initiating cell (HTIC) signature in MMTV-Her2/Neu mouse mammary TICs. Here, we show that patients with HTICS+ HER2+:ERα− tumors are more likely to achieve a pathologic complete response to trastuzumab-based neoadjuvant chemotherapy compared with HER2+:ER+ tumors. Neoadjuvant study of 50 HER2-positive breast cancer cases treated with trastuzumab-based chemotherapy pre-operatively. Pre-treatment FNA from primary tumors were obtained and RNA extracted and hybridized to Affymetrix microarrays according to manufacturer protocol. Pathologic response was assessed at the end of neoadjuvant treatment.

Species:: human
Samples:: 50
Source:: E-GEOD-37946
Updated:: Dec.12, 2014
Registered:: Jun.18, 2014

Factors: (via ArrayExpress)

Sample	PR	AGE	ER	RESPONSE	STAGE
GSM930574	NEG	49	NEG	RD	IV
GSM930573	POS	62	POS	RD	IIIC
GSM930572	POS	24	POS	RD	IIIC
GSM93057	NEG	54	NEG	RD	IIIC
GSM930570	POS	72	POS	RD	IIB
GSM930569	NEG	55	NEG	RD	IIIC
GSM930568	NEG	61	NEG	RD	IIIC
GSM930567	POS	48	POS	RD	IIIA
GSM930566	NEG	39	NEG	RD	IIIC
GSM930565	NEG	50	POS	RD	IIIA
GSM930564	NEG	44	NEG	RD	IIA
GSM930563	NEG	51	NEG	RD	IIB
GSM930562	NEG	61	POS	RD	IIB
GSM93056	NEG	30	NEG	RD	IIIB
GSM930560	NEG	52	NEG	RD	IIIA
GSM930559	NEG	69	NEG	RD	IIA
GSM930558	NEG	56	POS	RD	IIIC
GSM930557	NEG	73	NEG	RD	IIA
GSM930556	POS	47	POS	RD	IIIC
GSM930555	NEG	41	NEG	RD	IIIC
GSM930554	POS	49	POS	RD	IIA
GSM930553	POS	28	POS	RD	IIIB
GSM930552	NEG	57	NEG	RD	IIA
GSM93055	NEG	46	NEG	PCR	IIIC
GSM930550	POS	30	POS	PCR	not specified
GSM930549	NEG	65	NEG	PCR	IIB
GSM930548	POS	52	POS	PCR	IIIB
GSM930547	NEG	56	NEG	PCR	IIB
GSM93055	NEG	46	NEG	PCR	IIIC
GSM930545	POS	56	POS	PCR	IIIA
GSM930544	NEG	53	NEG	PCR	IIB
GSM930543	NEG	62	NEG	PCR	IIIC
GSM930542	NEG	55	NEG	PCR	IIA
GSM93054	NEG	51	NEG	PCR	IIIB
GSM930540	POS	53	POS	PCR	IIIA
GSM930539	NEG	41	NEG	PCR	IIIC
GSM930538	NEG	50	POS	PCR	IIIA
GSM930537	NEG	63	POS	PCR	IIA
GSM930536	NEG	38	POS	PCR	I
GSM930535	NEG	43	NEG	PCR	IIIA
GSM930534	NEG	51	NEG	PCR	IIIC
GSM930533	NEG	45	NEG	PCR	IIIC
GSM930532	POS	56	NEG	PCR	IIIA
GSM93053	NEG	47	NEG	PCR	IIA
GSM930530	NEG	36	NEG	PCR	I
GSM930529	POS	38	POS	PCR	IIA
GSM930528	NEG	30	NEG	PCR	IIIA
GSM930527	NEG	52	NEG	PCR	IIIB
GSM930526	NEG	34	NEG	PCR	IIA
GSM930525	NEG	50	NEG	PCR	IIA