Dataset: Expression data from 3 gamma-secretase or mock-treated mantle cell lymphoma (MCL) cell lines
We identified recurrent NOTCH1 mutations in 12% of MCLs. 2 out of 10 tested MCL cell lines (Rec-1 and SP-49) were sensitive to inhibition...
We identified recurrent NOTCH1 mutations in 12% of MCLs. 2 out of 10 tested MCL cell lines (Rec-1 and SP-49) were sensitive to inhibition of the NOTCH pathway by gamma-secretase inhibition. The aim of this study was to identify transcriptional targets of NOTCH signaling in MCL. 3 MCL cell lines (Mino, Rec-1, SP-49 treated with Mock or 1 micromolar compound E for 24 hours, in duplicate.
- Species:
- human
- Samples:
- 12
- Source:
- E-GEOD-34602
- Updated:
- Dec.12, 2014
- Registered:
- Sep.17, 2014
Factors:
(via ArrayExpress)
| Sample | CELL LINE |
|---|---|
| GSM85173 | Mino |
| GSM85173 | Mino |
| GSM85173 | Mino |
| GSM85173 | Mino |
| GSM851735 | Rec-1 |
| GSM851735 | Rec-1 |
| GSM851735 | Rec-1 |
| GSM851735 | Rec-1 |
| GSM851739 | SP-49 |
| GSM851739 | SP-49 |
| GSM851739 | SP-49 |
| GSM851739 | SP-49 |