Dataset: Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples....

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We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. Abnormal beta-catenin staining was associated with mitotic rate and poorer patient survival in the carcinomas. In a second independent data set (given in a supplement) we again found beta-catenin associated with poor survival. The array data given is the same as GEO series GSE10927, with additional characteristics about beta-catenin, and new patient followup data. The analysis shown in a supplementary Excel file is also new. Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. 23 of the carcinomas were used in survival analysis. 27 additional samples without array data were also used in a survival analysis.

Species:: human
Samples:: 65
Source:: E-GEOD-33371
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	YEARS TO LAST FOLLOWUP	WEISS SCORE OF TUMOR	TUMOR DIAMETER (CM)	AGE	TUMOR STAGE	BETA-CATENIN SEQUENCE RESULT	CLINICAL CHARACTERISTICS	SIDE OF BODY	TUMOR WEIGHT (GM)	MITOTIC RATE OF TUMOR	SEX	BETA-CATENIN STAINING	DEAD OR ALIVE AT LAST FOLLOWUP
GSM825367	unknown	not applicable	not applicable	71	not applicable	unknown	Adrenalectomy for metastatic lung carcinoma	left	not applicable	not applicable	F	Membrane	unknown
GSM825368	unknown	not applicable	not applicable	58	not applicable	unknown	Adrenalectomy for ACA; Conn's syndrome	right	not applicable	not applicable	F	unknown	unknown
GSM825369	unknown	not applicable	not applicable	71	not applicable	unknown	Adrenalectomy for renal cell carcinoma	right	not applicable	not applicable	M	unknown	unknown
GSM825370	unknown	not applicable	not applicable	44	not applicable	unknown	Adrenalectomy for ACA; Conn's syndrome	left	not applicable	not applicable	M	unknown	unknown
GSM82537	unknown	not applicable	not applicable	32	not applicable	unknown	Adrenalectomy for ACA	right	not applicable	not applicable	F	Membrane	unknown
GSM825372	unknown	not applicable	not applicable	28	not applicable	unknown	Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA)	left	not applicable	not applicable	M	Membrane	unknown
GSM825373	unknown	not applicable	not applicable	55	not applicable	unknown	Adrenalectomy for multinodular cortical hyperplasia; Conn's syndrome	left	not applicable	not applicable	M	Membrane	unknown
GSM825374	unknown	not applicable	not applicable	78	not applicable	unknown	Adrenalectomy for renal cell carcinoma	left	not applicable	not applicable	M	unknown	unknown
GSM825375	unknown	not applicable	not applicable	41	not applicable	unknown	Adrenalectomy for renal cell carcinoma	unknown	not applicable	not applicable	M	unknown	unknown
GSM825376	unknown	not applicable	not applicable	58	not applicable	unknown	Adrenalectomy for pheochromocytoma	left	not applicable	not applicable	M	unknown	unknown
GSM825377	unknown	not applicable	2.5	45	not applicable	wild type	Cushing syndrome	left	12.1	not applicable	F	Membrane	unknown
GSM825378	unknown	not applicable	3.5	28	not applicable	wild type	Cushing syndrome	left	25.2	not applicable	F	Membrane	unknown
GSM825379	unknown	not applicable	5.5	57	not applicable	wild type	Cushing syndrome	right	50	not applicable	F	Membrane	unknown
GSM825380	unknown	not applicable	2.5	25	not applicable	wild type	Cushing syndrome	right	16	not applicable	F	Membrane	unknown
GSM82538	unknown	not applicable	2.7	25	not applicable	wild type	Cushing syndrome	left	11.1	not applicable	F	Membrane	unknown
GSM825382	unknown	not applicable	2.2	56	not applicable	wild type	Hyperaldosteronism	right	8.2	not applicable	F	Membrane	unknown
GSM825383	unknown	not applicable	1.1	33	not applicable	wild type	Hyperaldosteronism	left	17.2	not applicable	F	Membrane	unknown
GSM825384	unknown	not applicable	unknown	44	not applicable	wild type	Aldosteronoma	left	10.5	not applicable	M	Membrane	unknown
GSM825385	unknown	not applicable	1.3	71	not applicable	wild type	Conn's syndrome	left	8.5	not applicable	F	Membrane	unknown
GSM825386	unknown	not applicable	1.5	56	not applicable	wild type	Left adrenal mass	left	7.6	not applicable	F	Membrane	unknown
GSM825387	unknown	not applicable	2.5	51	not applicable	wild type	Aldosteronoma	right	4.95	not applicable	F	Membrane	unknown
GSM825388	unknown	not applicable	5	32	not applicable	wild type	Hyperaldosteronism	right	14.9	not applicable	F	Membrane	unknown
GSM825389	unknown	not applicable	2.5	38	not applicable	wild type	Hyperaldosteronism	left	23.6	not applicable	M	Membrane	unknown
GSM825390	unknown	not applicable	4.2	49	not applicable	wild type	Bilateral adrenal masses	left	22.4	not applicable	F	Membrane	unknown
GSM82539	unknown	not applicable	3.3	62	not applicable	wild type	hypertension	right	65	not applicable	F	Nuclear	unknown
GSM825392	unknown	not applicable	7	59	not applicable	wild type	Right adrenal mass	right	95	not applicable	M	Nuclear	unknown
GSM825393	unknown	not applicable	6.2	52	not applicable	mutant	Left adrenal mass	left	57	not applicable	M	Membrane	unknown
GSM825394	unknown	not applicable	3.5	54	not applicable	mutant	Right pheochromocytoma	right	12.5	not applicable	F	Nuclear	unknown
GSM825395	unknown	not applicable	9	48	not applicable	mutant	abdominal pain	left	174.5	not applicable	M	Membrane	unknown
GSM825396	unknown	not applicable	4.5	55	not applicable	mutant	Cushing syndrome	left	31	not applicable	M	Membrane	unknown
GSM825397	unknown	not applicable	7.2	64	not applicable	mutant	Right adrenal mass	right	116	not applicable	F	Membrane	unknown
GSM825398	unknown	not applicable	5.5	45	not applicable	mutant	Left adrenal mass	left	45	not applicable	M	Nuclear	unknown
GSM825399	12.46849315	High	3.2	<10	1	unknown	Virilization and microcephaly	right	12	22	F	Membrane	alive
GSM825400	6.55	Low	unknown	49	4	unknown	Status post adrenalectomy	not applicable	unknown	6	F	Membrane	alive
GSM82540	1.512328767	High	9	45	2	unknown	Left adrenal mass	left	180	24	F	Membrane	dead
GSM825402	1.657534247	High	unknown	48	4	unknown	History of Adrenocortical carcinoma	not applicable	unknown	51	F	Membrane	dead
GSM825403	1.202739726	High	unknown	77	4	unknown	Tumor of left hepatic lobe	not applicable	unknown	45	M	Membrane	dead
GSM825404	1.29	High	16	47	2	unknown	Left adrenal mass	left	unknown	41	F	Membrane	alive
GSM825405	unknown	Low	5.5	55	2	unknown	Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumor	left	35.1	4	M	Membrane	unknown
GSM825406	2.780821918	Low	19	52	2	unknown	Right adrenal mass	right	2890	2	F	Membrane	dead
GSM825407	0.775342466	High	9.2	34	2	unknown	unknown	left	266	74	M	Membrane	dead
GSM825408	1.232876712	Low	16	35	4	unknown	History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year prior	left	460	8	F	Membrane	dead
GSM825409	unknown	Low	19	52	2	unknown	Left adrenal mass	left	2310	1	M	Membrane	unknown
GSM825410	5.56	Low	6.2	48	2	unknown	Left adrenal mass	left	110	4	M	Membrane	alive
GSM8254	8.95	Low	5	45	2	unknown	unknown	left	60	2	M	Membrane	alive
GSM825412	0.090410959	High	18	39	3	unknown	Cushing syndrome	left	900	109	F	Membrane	dead
GSM825413	unknown	Low	15.5	40	3	unknown	Left adrenal mass	left	unknown	9	F	Membrane	unknown
GSM825414	15.12	High	12	31	2	unknown	Liver tumor; Severe abdominal pain	right	520	65	F	Membrane	alive
GSM825415	unknown	Low	16.5	87	2	unknown	unknown	left	1690.4	0	F	Membrane	unknown
GSM825416	0.120547945	High	9	45	4	unknown	Right flank pain; Masses in right kidney, liver and both lungs	right	unknown	137	F	Membrane	dead
GSM825417	4.753424658	Low	17	41	3	unknown	Left adrenal mass	left	2540	12	F	Membrane	dead
GSM825418	0.476712329	High	12	<10	4	unknown	Increased testosterone	left	450	64	M	Nuclear	dead
GSM825419	unknown	Low	8.5	32	2	unknown	Hyperaldosteronism	right	400	7	F	Nuclear	unknown
GSM825420	unknown	High	15	50	2	unknown	Left adrenal mass	left	360	45	M	Nuclear	unknown
GSM82542	unknown	Low	10	55	2	unknown	Hyperaldosteronism	left	212	15	F	Nuclear	unknown
GSM825422	0.619178082	High	10.5	19	2	unknown	Left adrenal mass	left	unknown	27	M	Nuclear	dead
GSM825423	0.942465753	High	9.8	61	2	unknown	Cushing syndrome	right	253	27	F	Nuclear	dead
GSM825424	unknown	High	13	33	3	unknown	Cortisol secreting tumor	left	660	70	F	Nuclear	unknown
GSM825425	unknown	Low	unknown	31	4	unknown	History of Adrenocortical carcinoma	not applicable	unknown	16	F	Nuclear	unknown
GSM825426	0.364383562	High	18.5	60	2	unknown	Cushing syndrome	right	1805	40	F	Nuclear	dead
GSM825427	2.232876712	High	15.5	51	3	unknown	Right adrenal mass; elevated androgens and cortisol	right	1305	23	F	Nuclear	dead
GSM825428	0.624657534	High	22	71	4	unknown	Right adrenal tumor; Leg edema	right	2440	22	M	Nuclear	dead
GSM825429	0.898630137	High	26	25	4	unknown	History of adrenal mass; 2 month history of abdominal pain	right	2300	34	F	Nuclear	dead
GSM825430	7.81	High	unknown	47	1	unknown	Cushing Syndrome; Right adrenalectomy 4 years prior	right	unknown	37	F	Nuclear	alive
GSM82543	unknown	High	8.7	49	2	unknown	Elevated serum aldosterone and DHEA-S; History of left nephrectomy	left	397	28	F	unknown	unknown