Dataset: Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples....

Registered by ArrayExpress Uploader

View Dataset

We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. Abnormal beta-catenin staining was associated with mitotic rate and poorer patient survival in the carcinomas. In a second independent data set (given in a supplement) we again found beta-catenin associated with poor survival. The array data given is the same as GEO series GSE10927, with additional characteristics about beta-catenin, and new patient followup data. The analysis shown in a supplementary Excel file is also new. Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. 23 of the carcinomas were used in survival analysis. 27 additional samples without array data were also used in a survival analysis.

Species:: human
Samples:: 65
Source:: E-GEOD-33371
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	YEARS TO LAST FOLLOWUP	WEISS SCORE OF TUMOR	TUMOR DIAMETER (CM)	AGE	TUMOR STAGE	SEX	CLINICAL CHARACTERISTICS	SIDE OF BODY	TUMOR WEIGHT (GM)	MITOTIC RATE OF TUMOR	BETA-CATENIN SEQUENCE RESULT	BETA-CATENIN STAINING	DEAD OR ALIVE AT LAST FOLLOWUP
GSM825367	unknown	not applicable	not applicable	71	not applicable	F	Adrenalectomy for metastatic lung carcinoma	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825368	unknown	not applicable	not applicable	58	not applicable	F	Adrenalectomy for ACA; Conn's syndrome	right	not applicable	not applicable	unknown	unknown	unknown
GSM825369	unknown	not applicable	not applicable	71	not applicable	M	Adrenalectomy for renal cell carcinoma	right	not applicable	not applicable	unknown	unknown	unknown
GSM825370	unknown	not applicable	not applicable	44	not applicable	M	Adrenalectomy for ACA; Conn's syndrome	left	not applicable	not applicable	unknown	unknown	unknown
GSM82537	unknown	not applicable	not applicable	32	not applicable	F	Adrenalectomy for ACA	right	not applicable	not applicable	unknown	Membrane	unknown
GSM825372	unknown	not applicable	not applicable	28	not applicable	M	Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA)	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825373	unknown	not applicable	not applicable	55	not applicable	M	Adrenalectomy for multinodular cortical hyperplasia; Conn's syndrome	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825374	unknown	not applicable	not applicable	78	not applicable	M	Adrenalectomy for renal cell carcinoma	left	not applicable	not applicable	unknown	unknown	unknown
GSM825375	unknown	not applicable	not applicable	41	not applicable	M	Adrenalectomy for renal cell carcinoma	unknown	not applicable	not applicable	unknown	unknown	unknown
GSM825376	unknown	not applicable	not applicable	58	not applicable	M	Adrenalectomy for pheochromocytoma	left	not applicable	not applicable	unknown	unknown	unknown
GSM825377	unknown	not applicable	2.5	45	not applicable	F	Cushing syndrome	left	12.1	not applicable	wild type	Membrane	unknown
GSM825378	unknown	not applicable	3.5	28	not applicable	F	Cushing syndrome	left	25.2	not applicable	wild type	Membrane	unknown
GSM825379	unknown	not applicable	5.5	57	not applicable	F	Cushing syndrome	right	50	not applicable	wild type	Membrane	unknown
GSM825380	unknown	not applicable	2.5	25	not applicable	F	Cushing syndrome	right	16	not applicable	wild type	Membrane	unknown
GSM82538	unknown	not applicable	2.7	25	not applicable	F	Cushing syndrome	left	11.1	not applicable	wild type	Membrane	unknown
GSM825382	unknown	not applicable	2.2	56	not applicable	F	Hyperaldosteronism	right	8.2	not applicable	wild type	Membrane	unknown
GSM825383	unknown	not applicable	1.1	33	not applicable	F	Hyperaldosteronism	left	17.2	not applicable	wild type	Membrane	unknown
GSM825384	unknown	not applicable	unknown	44	not applicable	M	Aldosteronoma	left	10.5	not applicable	wild type	Membrane	unknown
GSM825385	unknown	not applicable	1.3	71	not applicable	F	Conn's syndrome	left	8.5	not applicable	wild type	Membrane	unknown
GSM825386	unknown	not applicable	1.5	56	not applicable	F	Left adrenal mass	left	7.6	not applicable	wild type	Membrane	unknown
GSM825387	unknown	not applicable	2.5	51	not applicable	F	Aldosteronoma	right	4.95	not applicable	wild type	Membrane	unknown
GSM825388	unknown	not applicable	5	32	not applicable	F	Hyperaldosteronism	right	14.9	not applicable	wild type	Membrane	unknown
GSM825389	unknown	not applicable	2.5	38	not applicable	M	Hyperaldosteronism	left	23.6	not applicable	wild type	Membrane	unknown
GSM825390	unknown	not applicable	4.2	49	not applicable	F	Bilateral adrenal masses	left	22.4	not applicable	wild type	Membrane	unknown
GSM82539	unknown	not applicable	3.3	62	not applicable	F	hypertension	right	65	not applicable	wild type	Nuclear	unknown
GSM825392	unknown	not applicable	7	59	not applicable	M	Right adrenal mass	right	95	not applicable	wild type	Nuclear	unknown
GSM825393	unknown	not applicable	6.2	52	not applicable	M	Left adrenal mass	left	57	not applicable	mutant	Membrane	unknown
GSM825394	unknown	not applicable	3.5	54	not applicable	F	Right pheochromocytoma	right	12.5	not applicable	mutant	Nuclear	unknown
GSM825395	unknown	not applicable	9	48	not applicable	M	abdominal pain	left	174.5	not applicable	mutant	Membrane	unknown
GSM825396	unknown	not applicable	4.5	55	not applicable	M	Cushing syndrome	left	31	not applicable	mutant	Membrane	unknown
GSM825397	unknown	not applicable	7.2	64	not applicable	F	Right adrenal mass	right	116	not applicable	mutant	Membrane	unknown
GSM825398	unknown	not applicable	5.5	45	not applicable	M	Left adrenal mass	left	45	not applicable	mutant	Nuclear	unknown
GSM825399	12.46849315	High	3.2	<10	1	F	Virilization and microcephaly	right	12	22	unknown	Membrane	alive
GSM825400	6.55	Low	unknown	49	4	F	Status post adrenalectomy	not applicable	unknown	6	unknown	Membrane	alive
GSM82540	1.512328767	High	9	45	2	F	Left adrenal mass	left	180	24	unknown	Membrane	dead
GSM825402	1.657534247	High	unknown	48	4	F	History of Adrenocortical carcinoma	not applicable	unknown	51	unknown	Membrane	dead
GSM825403	1.202739726	High	unknown	77	4	M	Tumor of left hepatic lobe	not applicable	unknown	45	unknown	Membrane	dead
GSM825404	1.29	High	16	47	2	F	Left adrenal mass	left	unknown	41	unknown	Membrane	alive
GSM825405	unknown	Low	5.5	55	2	M	Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumor	left	35.1	4	unknown	Membrane	unknown
GSM825406	2.780821918	Low	19	52	2	F	Right adrenal mass	right	2890	2	unknown	Membrane	dead
GSM825407	0.775342466	High	9.2	34	2	M	unknown	left	266	74	unknown	Membrane	dead
GSM825408	1.232876712	Low	16	35	4	F	History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year prior	left	460	8	unknown	Membrane	dead
GSM825409	unknown	Low	19	52	2	M	Left adrenal mass	left	2310	1	unknown	Membrane	unknown
GSM825410	5.56	Low	6.2	48	2	M	Left adrenal mass	left	110	4	unknown	Membrane	alive
GSM8254	8.95	Low	5	45	2	M	unknown	left	60	2	unknown	Membrane	alive
GSM825412	0.090410959	High	18	39	3	F	Cushing syndrome	left	900	109	unknown	Membrane	dead
GSM825413	unknown	Low	15.5	40	3	F	Left adrenal mass	left	unknown	9	unknown	Membrane	unknown
GSM825414	15.12	High	12	31	2	F	Liver tumor; Severe abdominal pain	right	520	65	unknown	Membrane	alive
GSM825415	unknown	Low	16.5	87	2	F	unknown	left	1690.4	0	unknown	Membrane	unknown
GSM825416	0.120547945	High	9	45	4	F	Right flank pain; Masses in right kidney, liver and both lungs	right	unknown	137	unknown	Membrane	dead
GSM825417	4.753424658	Low	17	41	3	F	Left adrenal mass	left	2540	12	unknown	Membrane	dead
GSM825418	0.476712329	High	12	<10	4	M	Increased testosterone	left	450	64	unknown	Nuclear	dead
GSM825419	unknown	Low	8.5	32	2	F	Hyperaldosteronism	right	400	7	unknown	Nuclear	unknown
GSM825420	unknown	High	15	50	2	M	Left adrenal mass	left	360	45	unknown	Nuclear	unknown
GSM82542	unknown	Low	10	55	2	F	Hyperaldosteronism	left	212	15	unknown	Nuclear	unknown
GSM825422	0.619178082	High	10.5	19	2	M	Left adrenal mass	left	unknown	27	unknown	Nuclear	dead
GSM825423	0.942465753	High	9.8	61	2	F	Cushing syndrome	right	253	27	unknown	Nuclear	dead
GSM825424	unknown	High	13	33	3	F	Cortisol secreting tumor	left	660	70	unknown	Nuclear	unknown
GSM825425	unknown	Low	unknown	31	4	F	History of Adrenocortical carcinoma	not applicable	unknown	16	unknown	Nuclear	unknown
GSM825426	0.364383562	High	18.5	60	2	F	Cushing syndrome	right	1805	40	unknown	Nuclear	dead
GSM825427	2.232876712	High	15.5	51	3	F	Right adrenal mass; elevated androgens and cortisol	right	1305	23	unknown	Nuclear	dead
GSM825428	0.624657534	High	22	71	4	M	Right adrenal tumor; Leg edema	right	2440	22	unknown	Nuclear	dead
GSM825429	0.898630137	High	26	25	4	F	History of adrenal mass; 2 month history of abdominal pain	right	2300	34	unknown	Nuclear	dead
GSM825430	7.81	High	unknown	47	1	F	Cushing Syndrome; Right adrenalectomy 4 years prior	right	unknown	37	unknown	Nuclear	alive
GSM82543	unknown	High	8.7	49	2	F	Elevated serum aldosterone and DHEA-S; History of left nephrectomy	left	397	28	unknown	unknown	unknown