Dataset: Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples....

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We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. Abnormal beta-catenin staining was associated with mitotic rate and poorer patient survival in the carcinomas. In a second independent data set (given in a supplement) we again found beta-catenin associated with poor survival. The array data given is the same as GEO series GSE10927, with additional characteristics about beta-catenin, and new patient followup data. The analysis shown in a supplementary Excel file is also new. Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. 23 of the carcinomas were used in survival analysis. 27 additional samples without array data were also used in a survival analysis.

Species:: human
Samples:: 65
Source:: E-GEOD-33371
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	YEARS TO LAST FOLLOWUP	CLINICAL CHARACTERISTICS	TUMOR DIAMETER (CM)	AGE	TUMOR STAGE	SEX	WEISS SCORE OF TUMOR	SIDE OF BODY	TUMOR WEIGHT (GM)	MITOTIC RATE OF TUMOR	BETA-CATENIN SEQUENCE RESULT	BETA-CATENIN STAINING	DEAD OR ALIVE AT LAST FOLLOWUP
GSM825367	unknown	Adrenalectomy for metastatic lung carcinoma	not applicable	71	not applicable	F	not applicable	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825368	unknown	Adrenalectomy for ACA; Conn's syndrome	not applicable	58	not applicable	F	not applicable	right	not applicable	not applicable	unknown	unknown	unknown
GSM825369	unknown	Adrenalectomy for renal cell carcinoma	not applicable	71	not applicable	M	not applicable	right	not applicable	not applicable	unknown	unknown	unknown
GSM825370	unknown	Adrenalectomy for ACA; Conn's syndrome	not applicable	44	not applicable	M	not applicable	left	not applicable	not applicable	unknown	unknown	unknown
GSM82537	unknown	Adrenalectomy for ACA	not applicable	32	not applicable	F	not applicable	right	not applicable	not applicable	unknown	Membrane	unknown
GSM825372	unknown	Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA)	not applicable	28	not applicable	M	not applicable	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825373	unknown	Adrenalectomy for multinodular cortical hyperplasia; Conn's syndrome	not applicable	55	not applicable	M	not applicable	left	not applicable	not applicable	unknown	Membrane	unknown
GSM825374	unknown	Adrenalectomy for renal cell carcinoma	not applicable	78	not applicable	M	not applicable	left	not applicable	not applicable	unknown	unknown	unknown
GSM825375	unknown	Adrenalectomy for renal cell carcinoma	not applicable	41	not applicable	M	not applicable	unknown	not applicable	not applicable	unknown	unknown	unknown
GSM825376	unknown	Adrenalectomy for pheochromocytoma	not applicable	58	not applicable	M	not applicable	left	not applicable	not applicable	unknown	unknown	unknown
GSM825377	unknown	Cushing syndrome	2.5	45	not applicable	F	not applicable	left	12.1	not applicable	wild type	Membrane	unknown
GSM825378	unknown	Cushing syndrome	3.5	28	not applicable	F	not applicable	left	25.2	not applicable	wild type	Membrane	unknown
GSM825379	unknown	Cushing syndrome	5.5	57	not applicable	F	not applicable	right	50	not applicable	wild type	Membrane	unknown
GSM825380	unknown	Cushing syndrome	2.5	25	not applicable	F	not applicable	right	16	not applicable	wild type	Membrane	unknown
GSM82538	unknown	Cushing syndrome	2.7	25	not applicable	F	not applicable	left	11.1	not applicable	wild type	Membrane	unknown
GSM825382	unknown	Hyperaldosteronism	2.2	56	not applicable	F	not applicable	right	8.2	not applicable	wild type	Membrane	unknown
GSM825383	unknown	Hyperaldosteronism	1.1	33	not applicable	F	not applicable	left	17.2	not applicable	wild type	Membrane	unknown
GSM825384	unknown	Aldosteronoma	unknown	44	not applicable	M	not applicable	left	10.5	not applicable	wild type	Membrane	unknown
GSM825385	unknown	Conn's syndrome	1.3	71	not applicable	F	not applicable	left	8.5	not applicable	wild type	Membrane	unknown
GSM825386	unknown	Left adrenal mass	1.5	56	not applicable	F	not applicable	left	7.6	not applicable	wild type	Membrane	unknown
GSM825387	unknown	Aldosteronoma	2.5	51	not applicable	F	not applicable	right	4.95	not applicable	wild type	Membrane	unknown
GSM825388	unknown	Hyperaldosteronism	5	32	not applicable	F	not applicable	right	14.9	not applicable	wild type	Membrane	unknown
GSM825389	unknown	Hyperaldosteronism	2.5	38	not applicable	M	not applicable	left	23.6	not applicable	wild type	Membrane	unknown
GSM825390	unknown	Bilateral adrenal masses	4.2	49	not applicable	F	not applicable	left	22.4	not applicable	wild type	Membrane	unknown
GSM82539	unknown	hypertension	3.3	62	not applicable	F	not applicable	right	65	not applicable	wild type	Nuclear	unknown
GSM825392	unknown	Right adrenal mass	7	59	not applicable	M	not applicable	right	95	not applicable	wild type	Nuclear	unknown
GSM825393	unknown	Left adrenal mass	6.2	52	not applicable	M	not applicable	left	57	not applicable	mutant	Membrane	unknown
GSM825394	unknown	Right pheochromocytoma	3.5	54	not applicable	F	not applicable	right	12.5	not applicable	mutant	Nuclear	unknown
GSM825395	unknown	abdominal pain	9	48	not applicable	M	not applicable	left	174.5	not applicable	mutant	Membrane	unknown
GSM825396	unknown	Cushing syndrome	4.5	55	not applicable	M	not applicable	left	31	not applicable	mutant	Membrane	unknown
GSM825397	unknown	Right adrenal mass	7.2	64	not applicable	F	not applicable	right	116	not applicable	mutant	Membrane	unknown
GSM825398	unknown	Left adrenal mass	5.5	45	not applicable	M	not applicable	left	45	not applicable	mutant	Nuclear	unknown
GSM825399	12.46849315	Virilization and microcephaly	3.2	<10	1	F	High	right	12	22	unknown	Membrane	alive
GSM825400	6.55	Status post adrenalectomy	unknown	49	4	F	Low	not applicable	unknown	6	unknown	Membrane	alive
GSM82540	1.512328767	Left adrenal mass	9	45	2	F	High	left	180	24	unknown	Membrane	dead
GSM825402	1.657534247	History of Adrenocortical carcinoma	unknown	48	4	F	High	not applicable	unknown	51	unknown	Membrane	dead
GSM825403	1.202739726	Tumor of left hepatic lobe	unknown	77	4	M	High	not applicable	unknown	45	unknown	Membrane	dead
GSM825404	1.29	Left adrenal mass	16	47	2	F	High	left	unknown	41	unknown	Membrane	alive
GSM825405	unknown	Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumor	5.5	55	2	M	Low	left	35.1	4	unknown	Membrane	unknown
GSM825406	2.780821918	Right adrenal mass	19	52	2	F	Low	right	2890	2	unknown	Membrane	dead
GSM825407	0.775342466	unknown	9.2	34	2	M	High	left	266	74	unknown	Membrane	dead
GSM825408	1.232876712	History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year prior	16	35	4	F	Low	left	460	8	unknown	Membrane	dead
GSM825409	unknown	Left adrenal mass	19	52	2	M	Low	left	2310	1	unknown	Membrane	unknown
GSM825410	5.56	Left adrenal mass	6.2	48	2	M	Low	left	110	4	unknown	Membrane	alive
GSM8254	8.95	unknown	5	45	2	M	Low	left	60	2	unknown	Membrane	alive
GSM825412	0.090410959	Cushing syndrome	18	39	3	F	High	left	900	109	unknown	Membrane	dead
GSM825413	unknown	Left adrenal mass	15.5	40	3	F	Low	left	unknown	9	unknown	Membrane	unknown
GSM825414	15.12	Liver tumor; Severe abdominal pain	12	31	2	F	High	right	520	65	unknown	Membrane	alive
GSM825415	unknown	unknown	16.5	87	2	F	Low	left	1690.4	0	unknown	Membrane	unknown
GSM825416	0.120547945	Right flank pain; Masses in right kidney, liver and both lungs	9	45	4	F	High	right	unknown	137	unknown	Membrane	dead
GSM825417	4.753424658	Left adrenal mass	17	41	3	F	Low	left	2540	12	unknown	Membrane	dead
GSM825418	0.476712329	Increased testosterone	12	<10	4	M	High	left	450	64	unknown	Nuclear	dead
GSM825419	unknown	Hyperaldosteronism	8.5	32	2	F	Low	right	400	7	unknown	Nuclear	unknown
GSM825420	unknown	Left adrenal mass	15	50	2	M	High	left	360	45	unknown	Nuclear	unknown
GSM82542	unknown	Hyperaldosteronism	10	55	2	F	Low	left	212	15	unknown	Nuclear	unknown
GSM825422	0.619178082	Left adrenal mass	10.5	19	2	M	High	left	unknown	27	unknown	Nuclear	dead
GSM825423	0.942465753	Cushing syndrome	9.8	61	2	F	High	right	253	27	unknown	Nuclear	dead
GSM825424	unknown	Cortisol secreting tumor	13	33	3	F	High	left	660	70	unknown	Nuclear	unknown
GSM825425	unknown	History of Adrenocortical carcinoma	unknown	31	4	F	Low	not applicable	unknown	16	unknown	Nuclear	unknown
GSM825426	0.364383562	Cushing syndrome	18.5	60	2	F	High	right	1805	40	unknown	Nuclear	dead
GSM825427	2.232876712	Right adrenal mass; elevated androgens and cortisol	15.5	51	3	F	High	right	1305	23	unknown	Nuclear	dead
GSM825428	0.624657534	Right adrenal tumor; Leg edema	22	71	4	M	High	right	2440	22	unknown	Nuclear	dead
GSM825429	0.898630137	History of adrenal mass; 2 month history of abdominal pain	26	25	4	F	High	right	2300	34	unknown	Nuclear	dead
GSM825430	7.81	Cushing Syndrome; Right adrenalectomy 4 years prior	unknown	47	1	F	High	right	unknown	37	unknown	Nuclear	alive
GSM82543	unknown	Elevated serum aldosterone and DHEA-S; History of left nephrectomy	8.7	49	2	F	High	left	397	28	unknown	unknown	unknown