Dataset: Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)

We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples....

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We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. Abnormal beta-catenin staining was associated with mitotic rate and poorer patient survival in the carcinomas. In a second independent data set (given in a supplement) we again found beta-catenin associated with poor survival. The array data given is the same as GEO series GSE10927, with additional characteristics about beta-catenin, and new patient followup data. The analysis shown in a supplementary Excel file is also new. Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. 23 of the carcinomas were used in survival analysis. 27 additional samples without array data were also used in a survival analysis.

Species:: human
Samples:: 65
Source:: E-GEOD-33371
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	SEX	YEARS TO LAST FOLLOWUP	CLINICAL CHARACTERISTICS	TUMOR DIAMETER (CM)	AGE	TUMOR STAGE	BETA-CATENIN SEQUENCE RESULT	WEISS SCORE OF TUMOR	SIDE OF BODY	TUMOR WEIGHT (GM)	MITOTIC RATE OF TUMOR	BETA-CATENIN STAINING	DEAD OR ALIVE AT LAST FOLLOWUP
GSM825367	F	unknown	Adrenalectomy for metastatic lung carcinoma	not applicable	71	not applicable	unknown	not applicable	left	not applicable	not applicable	Membrane	unknown
GSM825368	F	unknown	Adrenalectomy for ACA; Conn's syndrome	not applicable	58	not applicable	unknown	not applicable	right	not applicable	not applicable	unknown	unknown
GSM825369	M	unknown	Adrenalectomy for renal cell carcinoma	not applicable	71	not applicable	unknown	not applicable	right	not applicable	not applicable	unknown	unknown
GSM825370	M	unknown	Adrenalectomy for ACA; Conn's syndrome	not applicable	44	not applicable	unknown	not applicable	left	not applicable	not applicable	unknown	unknown
GSM82537	F	unknown	Adrenalectomy for ACA	not applicable	32	not applicable	unknown	not applicable	right	not applicable	not applicable	Membrane	unknown
GSM825372	M	unknown	Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA)	not applicable	28	not applicable	unknown	not applicable	left	not applicable	not applicable	Membrane	unknown
GSM825373	M	unknown	Adrenalectomy for multinodular cortical hyperplasia; Conn's syndrome	not applicable	55	not applicable	unknown	not applicable	left	not applicable	not applicable	Membrane	unknown
GSM825374	M	unknown	Adrenalectomy for renal cell carcinoma	not applicable	78	not applicable	unknown	not applicable	left	not applicable	not applicable	unknown	unknown
GSM825375	M	unknown	Adrenalectomy for renal cell carcinoma	not applicable	41	not applicable	unknown	not applicable	unknown	not applicable	not applicable	unknown	unknown
GSM825376	M	unknown	Adrenalectomy for pheochromocytoma	not applicable	58	not applicable	unknown	not applicable	left	not applicable	not applicable	unknown	unknown
GSM825377	F	unknown	Cushing syndrome	2.5	45	not applicable	wild type	not applicable	left	12.1	not applicable	Membrane	unknown
GSM825378	F	unknown	Cushing syndrome	3.5	28	not applicable	wild type	not applicable	left	25.2	not applicable	Membrane	unknown
GSM825379	F	unknown	Cushing syndrome	5.5	57	not applicable	wild type	not applicable	right	50	not applicable	Membrane	unknown
GSM825380	F	unknown	Cushing syndrome	2.5	25	not applicable	wild type	not applicable	right	16	not applicable	Membrane	unknown
GSM82538	F	unknown	Cushing syndrome	2.7	25	not applicable	wild type	not applicable	left	11.1	not applicable	Membrane	unknown
GSM825382	F	unknown	Hyperaldosteronism	2.2	56	not applicable	wild type	not applicable	right	8.2	not applicable	Membrane	unknown
GSM825383	F	unknown	Hyperaldosteronism	1.1	33	not applicable	wild type	not applicable	left	17.2	not applicable	Membrane	unknown
GSM825384	M	unknown	Aldosteronoma	unknown	44	not applicable	wild type	not applicable	left	10.5	not applicable	Membrane	unknown
GSM825385	F	unknown	Conn's syndrome	1.3	71	not applicable	wild type	not applicable	left	8.5	not applicable	Membrane	unknown
GSM825386	F	unknown	Left adrenal mass	1.5	56	not applicable	wild type	not applicable	left	7.6	not applicable	Membrane	unknown
GSM825387	F	unknown	Aldosteronoma	2.5	51	not applicable	wild type	not applicable	right	4.95	not applicable	Membrane	unknown
GSM825388	F	unknown	Hyperaldosteronism	5	32	not applicable	wild type	not applicable	right	14.9	not applicable	Membrane	unknown
GSM825389	M	unknown	Hyperaldosteronism	2.5	38	not applicable	wild type	not applicable	left	23.6	not applicable	Membrane	unknown
GSM825390	F	unknown	Bilateral adrenal masses	4.2	49	not applicable	wild type	not applicable	left	22.4	not applicable	Membrane	unknown
GSM82539	F	unknown	hypertension	3.3	62	not applicable	wild type	not applicable	right	65	not applicable	Nuclear	unknown
GSM825392	M	unknown	Right adrenal mass	7	59	not applicable	wild type	not applicable	right	95	not applicable	Nuclear	unknown
GSM825393	M	unknown	Left adrenal mass	6.2	52	not applicable	mutant	not applicable	left	57	not applicable	Membrane	unknown
GSM825394	F	unknown	Right pheochromocytoma	3.5	54	not applicable	mutant	not applicable	right	12.5	not applicable	Nuclear	unknown
GSM825395	M	unknown	abdominal pain	9	48	not applicable	mutant	not applicable	left	174.5	not applicable	Membrane	unknown
GSM825396	M	unknown	Cushing syndrome	4.5	55	not applicable	mutant	not applicable	left	31	not applicable	Membrane	unknown
GSM825397	F	unknown	Right adrenal mass	7.2	64	not applicable	mutant	not applicable	right	116	not applicable	Membrane	unknown
GSM825398	M	unknown	Left adrenal mass	5.5	45	not applicable	mutant	not applicable	left	45	not applicable	Nuclear	unknown
GSM825399	F	12.46849315	Virilization and microcephaly	3.2	<10	1	unknown	High	right	12	22	Membrane	alive
GSM825400	F	6.55	Status post adrenalectomy	unknown	49	4	unknown	Low	not applicable	unknown	6	Membrane	alive
GSM82540	F	1.512328767	Left adrenal mass	9	45	2	unknown	High	left	180	24	Membrane	dead
GSM825402	F	1.657534247	History of Adrenocortical carcinoma	unknown	48	4	unknown	High	not applicable	unknown	51	Membrane	dead
GSM825403	M	1.202739726	Tumor of left hepatic lobe	unknown	77	4	unknown	High	not applicable	unknown	45	Membrane	dead
GSM825404	F	1.29	Left adrenal mass	16	47	2	unknown	High	left	unknown	41	Membrane	alive
GSM825405	M	unknown	Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumor	5.5	55	2	unknown	Low	left	35.1	4	Membrane	unknown
GSM825406	F	2.780821918	Right adrenal mass	19	52	2	unknown	Low	right	2890	2	Membrane	dead
GSM825407	M	0.775342466	unknown	9.2	34	2	unknown	High	left	266	74	Membrane	dead
GSM825408	F	1.232876712	History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year prior	16	35	4	unknown	Low	left	460	8	Membrane	dead
GSM825409	M	unknown	Left adrenal mass	19	52	2	unknown	Low	left	2310	1	Membrane	unknown
GSM825410	M	5.56	Left adrenal mass	6.2	48	2	unknown	Low	left	110	4	Membrane	alive
GSM8254	M	8.95	unknown	5	45	2	unknown	Low	left	60	2	Membrane	alive
GSM825412	F	0.090410959	Cushing syndrome	18	39	3	unknown	High	left	900	109	Membrane	dead
GSM825413	F	unknown	Left adrenal mass	15.5	40	3	unknown	Low	left	unknown	9	Membrane	unknown
GSM825414	F	15.12	Liver tumor; Severe abdominal pain	12	31	2	unknown	High	right	520	65	Membrane	alive
GSM825415	F	unknown	unknown	16.5	87	2	unknown	Low	left	1690.4	0	Membrane	unknown
GSM825416	F	0.120547945	Right flank pain; Masses in right kidney, liver and both lungs	9	45	4	unknown	High	right	unknown	137	Membrane	dead
GSM825417	F	4.753424658	Left adrenal mass	17	41	3	unknown	Low	left	2540	12	Membrane	dead
GSM825418	M	0.476712329	Increased testosterone	12	<10	4	unknown	High	left	450	64	Nuclear	dead
GSM825419	F	unknown	Hyperaldosteronism	8.5	32	2	unknown	Low	right	400	7	Nuclear	unknown
GSM825420	M	unknown	Left adrenal mass	15	50	2	unknown	High	left	360	45	Nuclear	unknown
GSM82542	F	unknown	Hyperaldosteronism	10	55	2	unknown	Low	left	212	15	Nuclear	unknown
GSM825422	M	0.619178082	Left adrenal mass	10.5	19	2	unknown	High	left	unknown	27	Nuclear	dead
GSM825423	F	0.942465753	Cushing syndrome	9.8	61	2	unknown	High	right	253	27	Nuclear	dead
GSM825424	F	unknown	Cortisol secreting tumor	13	33	3	unknown	High	left	660	70	Nuclear	unknown
GSM825425	F	unknown	History of Adrenocortical carcinoma	unknown	31	4	unknown	Low	not applicable	unknown	16	Nuclear	unknown
GSM825426	F	0.364383562	Cushing syndrome	18.5	60	2	unknown	High	right	1805	40	Nuclear	dead
GSM825427	F	2.232876712	Right adrenal mass; elevated androgens and cortisol	15.5	51	3	unknown	High	right	1305	23	Nuclear	dead
GSM825428	M	0.624657534	Right adrenal tumor; Leg edema	22	71	4	unknown	High	right	2440	22	Nuclear	dead
GSM825429	F	0.898630137	History of adrenal mass; 2 month history of abdominal pain	26	25	4	unknown	High	right	2300	34	Nuclear	dead
GSM825430	F	7.81	Cushing Syndrome; Right adrenalectomy 4 years prior	unknown	47	1	unknown	High	right	unknown	37	Nuclear	alive
GSM82543	F	unknown	Elevated serum aldosterone and DHEA-S; History of left nephrectomy	8.7	49	2	unknown	High	left	397	28	unknown	unknown