Dataset: Beta-catenin status effects in human adrenocortical carcinomas (33), adenomas (22), and normal adrenal cortex (10)
We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples....
We scored adrenocortical carcinomas and adenomas for abnormal beta-catenin staining, and sequenced the beta-catenin gene in some samples. We compared adrenocortincal carcinomas with and without abnormal beta-catenin staining and found many significant expression differences and significant results from enrichment testing. A similar comparison in the adenomas gave relatively few differences, and they did not correlate to differences found for the carcinomas. Abnormal beta-catenin staining was associated with mitotic rate and poorer patient survival in the carcinomas. In a second independent data set (given in a supplement) we again found beta-catenin associated with poor survival. The array data given is the same as GEO series GSE10927, with additional characteristics about beta-catenin, and new patient followup data. The analysis shown in a supplementary Excel file is also new. Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. 23 of the carcinomas were used in survival analysis. 27 additional samples without array data were also used in a survival analysis.
- Species:
- human
- Samples:
- 65
- Source:
- E-GEOD-33371
- Updated:
- Dec.12, 2014
- Registered:
- Sep.16, 2014
Sample | WEISS SCORE OF TUMOR | TUMOR DIAMETER (CM) | AGE | TUMOR STAGE | YEARS TO LAST FOLLOWUP | BETA-CATENIN SEQUENCE RESULT | CLINICAL CHARACTERISTICS | SIDE OF BODY | TUMOR WEIGHT (GM) | MITOTIC RATE OF TUMOR | SEX | BETA-CATENIN STAINING | DEAD OR ALIVE AT LAST FOLLOWUP |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GSM825367 | not applicable | not applicable | 71 | not applicable | unknown | unknown | Adrenalectomy for metastatic lung carcinoma | left | not applicable | not applicable | F | Membrane | unknown |
GSM825368 | not applicable | not applicable | 58 | not applicable | unknown | unknown | Adrenalectomy for ACA; Conn's syndrome | right | not applicable | not applicable | F | unknown | unknown |
GSM825369 | not applicable | not applicable | 71 | not applicable | unknown | unknown | Adrenalectomy for renal cell carcinoma | right | not applicable | not applicable | M | unknown | unknown |
GSM825370 | not applicable | not applicable | 44 | not applicable | unknown | unknown | Adrenalectomy for ACA; Conn's syndrome | left | not applicable | not applicable | M | unknown | unknown |
GSM82537 | not applicable | not applicable | 32 | not applicable | unknown | unknown | Adrenalectomy for ACA | right | not applicable | not applicable | F | Membrane | unknown |
GSM825372 | not applicable | not applicable | 28 | not applicable | unknown | unknown | Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA) | left | not applicable | not applicable | M | Membrane | unknown |
GSM825373 | not applicable | not applicable | 55 | not applicable | unknown | unknown | Adrenalectomy for multinodular cortical hyperplasia; Conn's syndrome | left | not applicable | not applicable | M | Membrane | unknown |
GSM825374 | not applicable | not applicable | 78 | not applicable | unknown | unknown | Adrenalectomy for renal cell carcinoma | left | not applicable | not applicable | M | unknown | unknown |
GSM825375 | not applicable | not applicable | 41 | not applicable | unknown | unknown | Adrenalectomy for renal cell carcinoma | unknown | not applicable | not applicable | M | unknown | unknown |
GSM825376 | not applicable | not applicable | 58 | not applicable | unknown | unknown | Adrenalectomy for pheochromocytoma | left | not applicable | not applicable | M | unknown | unknown |
GSM825377 | not applicable | 2.5 | 45 | not applicable | unknown | wild type | Cushing syndrome | left | 12.1 | not applicable | F | Membrane | unknown |
GSM825378 | not applicable | 3.5 | 28 | not applicable | unknown | wild type | Cushing syndrome | left | 25.2 | not applicable | F | Membrane | unknown |
GSM825379 | not applicable | 5.5 | 57 | not applicable | unknown | wild type | Cushing syndrome | right | 50 | not applicable | F | Membrane | unknown |
GSM825380 | not applicable | 2.5 | 25 | not applicable | unknown | wild type | Cushing syndrome | right | 16 | not applicable | F | Membrane | unknown |
GSM82538 | not applicable | 2.7 | 25 | not applicable | unknown | wild type | Cushing syndrome | left | 11.1 | not applicable | F | Membrane | unknown |
GSM825382 | not applicable | 2.2 | 56 | not applicable | unknown | wild type | Hyperaldosteronism | right | 8.2 | not applicable | F | Membrane | unknown |
GSM825383 | not applicable | 1.1 | 33 | not applicable | unknown | wild type | Hyperaldosteronism | left | 17.2 | not applicable | F | Membrane | unknown |
GSM825384 | not applicable | unknown | 44 | not applicable | unknown | wild type | Aldosteronoma | left | 10.5 | not applicable | M | Membrane | unknown |
GSM825385 | not applicable | 1.3 | 71 | not applicable | unknown | wild type | Conn's syndrome | left | 8.5 | not applicable | F | Membrane | unknown |
GSM825386 | not applicable | 1.5 | 56 | not applicable | unknown | wild type | Left adrenal mass | left | 7.6 | not applicable | F | Membrane | unknown |
GSM825387 | not applicable | 2.5 | 51 | not applicable | unknown | wild type | Aldosteronoma | right | 4.95 | not applicable | F | Membrane | unknown |
GSM825388 | not applicable | 5 | 32 | not applicable | unknown | wild type | Hyperaldosteronism | right | 14.9 | not applicable | F | Membrane | unknown |
GSM825389 | not applicable | 2.5 | 38 | not applicable | unknown | wild type | Hyperaldosteronism | left | 23.6 | not applicable | M | Membrane | unknown |
GSM825390 | not applicable | 4.2 | 49 | not applicable | unknown | wild type | Bilateral adrenal masses | left | 22.4 | not applicable | F | Membrane | unknown |
GSM82539 | not applicable | 3.3 | 62 | not applicable | unknown | wild type | hypertension | right | 65 | not applicable | F | Nuclear | unknown |
GSM825392 | not applicable | 7 | 59 | not applicable | unknown | wild type | Right adrenal mass | right | 95 | not applicable | M | Nuclear | unknown |
GSM825393 | not applicable | 6.2 | 52 | not applicable | unknown | mutant | Left adrenal mass | left | 57 | not applicable | M | Membrane | unknown |
GSM825394 | not applicable | 3.5 | 54 | not applicable | unknown | mutant | Right pheochromocytoma | right | 12.5 | not applicable | F | Nuclear | unknown |
GSM825395 | not applicable | 9 | 48 | not applicable | unknown | mutant | abdominal pain | left | 174.5 | not applicable | M | Membrane | unknown |
GSM825396 | not applicable | 4.5 | 55 | not applicable | unknown | mutant | Cushing syndrome | left | 31 | not applicable | M | Membrane | unknown |
GSM825397 | not applicable | 7.2 | 64 | not applicable | unknown | mutant | Right adrenal mass | right | 116 | not applicable | F | Membrane | unknown |
GSM825398 | not applicable | 5.5 | 45 | not applicable | unknown | mutant | Left adrenal mass | left | 45 | not applicable | M | Nuclear | unknown |
GSM825399 | High | 3.2 | <10 | 1 | 12.46849315 | unknown | Virilization and microcephaly | right | 12 | 22 | F | Membrane | alive |
GSM825400 | Low | unknown | 49 | 4 | 6.55 | unknown | Status post adrenalectomy | not applicable | unknown | 6 | F | Membrane | alive |
GSM82540 | High | 9 | 45 | 2 | 1.512328767 | unknown | Left adrenal mass | left | 180 | 24 | F | Membrane | dead |
GSM825402 | High | unknown | 48 | 4 | 1.657534247 | unknown | History of Adrenocortical carcinoma | not applicable | unknown | 51 | F | Membrane | dead |
GSM825403 | High | unknown | 77 | 4 | 1.202739726 | unknown | Tumor of left hepatic lobe | not applicable | unknown | 45 | M | Membrane | dead |
GSM825404 | High | 16 | 47 | 2 | 1.29 | unknown | Left adrenal mass | left | unknown | 41 | F | Membrane | alive |
GSM825405 | Low | 5.5 | 55 | 2 | unknown | unknown | Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumor | left | 35.1 | 4 | M | Membrane | unknown |
GSM825406 | Low | 19 | 52 | 2 | 2.780821918 | unknown | Right adrenal mass | right | 2890 | 2 | F | Membrane | dead |
GSM825407 | High | 9.2 | 34 | 2 | 0.775342466 | unknown | unknown | left | 266 | 74 | M | Membrane | dead |
GSM825408 | Low | 16 | 35 | 4 | 1.232876712 | unknown | History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year prior | left | 460 | 8 | F | Membrane | dead |
GSM825409 | Low | 19 | 52 | 2 | unknown | unknown | Left adrenal mass | left | 2310 | 1 | M | Membrane | unknown |
GSM825410 | Low | 6.2 | 48 | 2 | 5.56 | unknown | Left adrenal mass | left | 110 | 4 | M | Membrane | alive |
GSM8254 | Low | 5 | 45 | 2 | 8.95 | unknown | unknown | left | 60 | 2 | M | Membrane | alive |
GSM825412 | High | 18 | 39 | 3 | 0.090410959 | unknown | Cushing syndrome | left | 900 | 109 | F | Membrane | dead |
GSM825413 | Low | 15.5 | 40 | 3 | unknown | unknown | Left adrenal mass | left | unknown | 9 | F | Membrane | unknown |
GSM825414 | High | 12 | 31 | 2 | 15.12 | unknown | Liver tumor; Severe abdominal pain | right | 520 | 65 | F | Membrane | alive |
GSM825415 | Low | 16.5 | 87 | 2 | unknown | unknown | unknown | left | 1690.4 | 0 | F | Membrane | unknown |
GSM825416 | High | 9 | 45 | 4 | 0.120547945 | unknown | Right flank pain; Masses in right kidney, liver and both lungs | right | unknown | 137 | F | Membrane | dead |
GSM825417 | Low | 17 | 41 | 3 | 4.753424658 | unknown | Left adrenal mass | left | 2540 | 12 | F | Membrane | dead |
GSM825418 | High | 12 | <10 | 4 | 0.476712329 | unknown | Increased testosterone | left | 450 | 64 | M | Nuclear | dead |
GSM825419 | Low | 8.5 | 32 | 2 | unknown | unknown | Hyperaldosteronism | right | 400 | 7 | F | Nuclear | unknown |
GSM825420 | High | 15 | 50 | 2 | unknown | unknown | Left adrenal mass | left | 360 | 45 | M | Nuclear | unknown |
GSM82542 | Low | 10 | 55 | 2 | unknown | unknown | Hyperaldosteronism | left | 212 | 15 | F | Nuclear | unknown |
GSM825422 | High | 10.5 | 19 | 2 | 0.619178082 | unknown | Left adrenal mass | left | unknown | 27 | M | Nuclear | dead |
GSM825423 | High | 9.8 | 61 | 2 | 0.942465753 | unknown | Cushing syndrome | right | 253 | 27 | F | Nuclear | dead |
GSM825424 | High | 13 | 33 | 3 | unknown | unknown | Cortisol secreting tumor | left | 660 | 70 | F | Nuclear | unknown |
GSM825425 | Low | unknown | 31 | 4 | unknown | unknown | History of Adrenocortical carcinoma | not applicable | unknown | 16 | F | Nuclear | unknown |
GSM825426 | High | 18.5 | 60 | 2 | 0.364383562 | unknown | Cushing syndrome | right | 1805 | 40 | F | Nuclear | dead |
GSM825427 | High | 15.5 | 51 | 3 | 2.232876712 | unknown | Right adrenal mass; elevated androgens and cortisol | right | 1305 | 23 | F | Nuclear | dead |
GSM825428 | High | 22 | 71 | 4 | 0.624657534 | unknown | Right adrenal tumor; Leg edema | right | 2440 | 22 | M | Nuclear | dead |
GSM825429 | High | 26 | 25 | 4 | 0.898630137 | unknown | History of adrenal mass; 2 month history of abdominal pain | right | 2300 | 34 | F | Nuclear | dead |
GSM825430 | High | unknown | 47 | 1 | 7.81 | unknown | Cushing Syndrome; Right adrenalectomy 4 years prior | right | unknown | 37 | F | Nuclear | alive |
GSM82543 | High | 8.7 | 49 | 2 | unknown | unknown | Elevated serum aldosterone and DHEA-S; History of left nephrectomy | left | 397 | 28 | F | unknown | unknown |