Dataset: Gene expression profiling in myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are a heterogenous group of hematopoietic stem cell disorders characterized by dysplastic blood cell...

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Myelodysplastic syndromes (MDS) are a heterogenous group of hematopoietic stem cell disorders characterized by dysplastic blood cell formation and peripheral blood cytopenias. Up to 30% of patients with MDS will progress to a highly chemotherapy-resistant secondary acute myeloid leukemia (sAML). We identified mutations in U2AF1 in MDS patients and patients with U2AF1 mutations are at an increased risk of developing sAML. We identified mutations in U2AF1 in patients with MDS and hypothesized that U2AF1 mutations may represent a novel mechanism that could alter gene expression in MDS. To elucidate gene expression changes associated with U2AF1 mutations, we analyzed the global mRNA expression profile obtained from bone marrow CD34+ cells purified from 5 MDS patients with a U2AF1 mutation, 10 MDS patients without a mutation, and 4 normal donors.

Species:: human
Samples:: 19
Source:: E-GEOD-30195
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	UPN	IPSS	PLATELET (X10^3/MCL)	GENOTYPE	CYTOGENETICS	WBC (X10^3/MCL)	BANKING DATE	AGE ON STUDY	ANC (X10^3/MCL)	CYTOGENETIC RISK GROUP	SEX	DISEASE STATE	RACE	BONE MARROW MYELOBLAST(%)	HEMOGLOBIN (G/DL)	FAB	DURATION OF DISEASE (MONTH)	CELL TYPE	DIAGNOSIS DATE
GSM747424	127804	0.5	195	no U2AF1 mutation	46, XY[20]	2.3	8/3/2005	64	1.4	Good	male	myelodysplastic syndrome	White	2	8.9	RA	0	CD34+ purified MDS bone marrow	2005-08-03
GSM747425	300813	0	243	U2AF1 mutation	46, XX[20]	2.7	7/12/2005	41	1.2	Good	female	myelodysplastic syndrome	White	2	12.2	RA	3	CD34+ purified MDS bone marrow	2005-04-26
GSM747426	321864	2.5	56	U2AF1 mutation	47,XX,+8[20]	1.9	10/3/2005	63	0.3	Intermediate	female	myelodysplastic syndrome	White	12	9.8	RAEB	0	CD34+ purified MDS bone marrow	2005-10-03
GSM747427	350460	0.5	37	no U2AF1 mutation	46, XY[20]	2.1	11/17/2006	30	1.6	Good	male	myelodysplastic syndrome	Black	4	7.5	RA	0	CD34+ purified MDS bone marrow	2006-11-17
GSM747428	372440	0	123	no U2AF1 mutation	46,XY[20]	2.9	5/5/2006	59	1.4	Good	male	myelodysplastic syndrome	White	2	13.8	RA	0	CD34+ purified MDS bone marrow	5/5/2006
GSM747429	421452	1	22	no U2AF1 mutation	46,XX[20]	3.3	11/4/2005	33	0.9	Good	female	myelodysplastic syndrome	White	10	8.3	RAEB	2	CD34+ purified MDS bone marrow	2005-09-30
GSM747430	431137	2	8	no U2AF1 mutation	46,XY,add(3)(q25),del(3)(p13),del(5)(q15q31),-6,+8,add(12)(p11.2),add(15)(p11.1), -18,+22[cp4]/44,sl,-8,-20,-22,+mar[cp5]/44,sl1,-del(3),-7,+2mar[cp5]/43,sl1,add(X)(q28),-add(12p),+12,-mar[cp6]	6.5	8/29/2006	54	4.6	Poor	male	myelodysplastic syndrome	White	7	8.2	RAEB	1	CD34+ purified MDS bone marrow	2006-07-05
GSM74743	497942	1	24	no U2AF1 mutation	46,XY,der(1;22)(q10;q10)[4]/46,XY[16]	4.1	1/18/2006	47	1.6	Intermediate	male	myelodysplastic syndrome	White	0	8.6	RA	0	CD34+ purified MDS bone marrow	2006-01-18
GSM747432	667720	1	61	no U2AF1 mutation	46,XX[20]	5.1	5/9/2006	65	2.3	Good	female	myelodysplastic syndrome	White	10	8.8	RAEB	0	CD34+ purified MDS bone marrow	2006-05-01
GSM747433	703653	0.5	27	no U2AF1 mutation	46,XX[20]	3	2/2/2005	20	0.6	Good	female	myelodysplastic syndrome	White	0	8.4	RA	0	CD34+ purified MDS bone marrow	2005-02-02
GSM747434	705782	1	28	no U2AF1 mutation	46,XY[20]	3.3	8/4/2006	34	1.7	Good	male	myelodysplastic syndrome	White	5	9.7	RAEB	0	CD34+ purified MDS bone marrow	2006-08-04
GSM747435	843623	1	64	U2AF1 mutation	46,XY,del(20)(q11.2q13.3)[2]/46,XY[18]	0.7	3/3/2003	59	0.4	Good	male	myelodysplastic syndrome	White	6	9.7	RAEB	0	CD34+ purified MDS bone marrow	2003-03-03
GSM747436	917011	0.5	107	U2AF1 mutation	46,XY,del(20)(q11.2)[12]/46,XY[8]	3.3	6/2/2006	80	0.5	Good	male	myelodysplastic syndrome	White	0	8.2	RA	0	CD34+ purified MDS bone marrow	2006-06-02
GSM747437	937954	3	35	U2AF1 mutation	47,XY,+8[1]/47,idem,del(16)(q12.1)[13]/48,idem,+Y,del(16)(q11.1)[5]/46,XY[1]	1.2	9/20/2005	50	0.3	Poor	male	myelodysplastic syndrome	White	12	9.9	RAEB	0	CD34+ purified MDS bone marrow	2005-09-12
GSM747438	989739	3	52	U2AF1 mutation	46,XY,del(7)(q21)[8]/46,XY[12]	1.2	9/30/2005	71	0.2	Poor	male	myelodysplastic syndrome	White	18	11	RAEB	1	CD34+ purified MDS bone marrow	2005-08-15
GSM747439	not specified	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	CD34+ purified control bone marrow	unknown
GSM747439	not specified	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	CD34+ purified control bone marrow	unknown
GSM747439	not specified	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	CD34+ purified control bone marrow	unknown
GSM747439	not specified	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	unknown	unknown	control	unknown	unknown	unknown	unknown	unknown	CD34+ purified control bone marrow	unknown