Dataset: Melanoma cell culture phenotypes

Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding...

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Recent trials with MAPK inhibitors have shown promising results in many patients with metastatic melanoma; however, nearly all responding patients experience disease relapse. We describe here how melanoma cells respond to MAPK inhibition in a phenotype-specific manner, suggesting that slow cycling invasive phenotype cells provide a treatment-resistant pool from which disease relapse may be derived. The implication is that while MAPK inhibition may successfully treat proliferating cells, another cell population needs to be addressed at the same time. 12 samples

Species:: human
Samples:: 12
Source:: E-GEOD-28335
PubMed:: 21176117
Updated:: Dec.12, 2014
Registered:: Sep.16, 2014

Factors: (via ArrayExpress)

Sample	CELL CULTURE PHENOTYPE	NRAS	CELL LINE	TUMOR STAGE	CELL ORIGIN	BRAF
GSM700742	proliferative	wt	M980513	T2aN3M1c	Lymph node metastasis iliacal	V600E
GSM700743	proliferative	Q61R	M010817	TxN1bM1c	Skin metastasis left upper arm	wt
GSM700744	proliferative	Q61L	M050829	T3aN3M0	Skin metastasis retrauricular right	wt
GSM700745	proliferative	wt	M000921	TxNxM1c	Epigastric metastasis	V600E
GSM700746	proliferative	G12D	M080423	T3bN1aM1a	Lymph node metastasis hepatoduodenal	wt
GSM700747	proliferative	wt	M080326	T4bN2aM0	Primary plantar	V600E
GSM700748	invasive	wt	M080306	T2N1bM0	Primary capillitium	wt
GSM700749	invasive	wt	M061103	T4N1bM0	Skin metastasis capillitium	wt
GSM700750	invasive	wt	M060125	TxNxM1c	Skin metastasis scapula	V600E
GSM70075	invasive	wt	M010119	T2bN3M0	Skin metastasis shoulder	L597S
GSM700752	invasive	wt	M081008	T1aN0M0	Primary face	wt
GSM700753	invasive	wt	M080307	T4N2M1c	Soft tissue metastasis axilla	wt