Dataset: Gene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and...
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and non-canonical targets genes in response to Wnt-1 as compared with controls. In regard to lymphangiogenic factors, the amount of VEGF-C was the single best marker to correlate with the amount of lymph-angiogenesis. mRNA expression array of human melanoma orthotopically grown in SCID mice. Comparison includes mRNA expression profile of two melanoma cell-lines (A375 and M24met) stably overexpressing control vector or Wnt-1 treated with or without CsA. Comparison #1 comprised Wnt-1 versus control in A375 and M24met melanoma, respectively. Comparison #2 comprised Wnt-1 + Cyclosporine A (CsA) versus Wnt-1 without CsA.
- Species:
- human
- Samples:
- 24
- Source:
- E-GEOD-26656
- PubMed:
- 22572818
- Updated:
- Dec.12, 2014
- Registered:
- Sep.15, 2014
| Sample | CELL LINE | TREATMENT | VARIATION |
|---|---|---|---|
| GSM656286 | A375 melanoma cell-line | control | wild type |
| GSM656286 | A375 melanoma cell-line | control | wild type |
| GSM656286 | A375 melanoma cell-line | control | wild type |
| GSM656286 | A375 melanoma cell-line | control | wild type |
| GSM656290 | A375 melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656290 | A375 melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656290 | A375 melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656293 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | wild type |
| GSM656293 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | wild type |
| GSM656293 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | wild type |
| GSM656293 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | wild type |
| GSM656297 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | Wnt-1 overexpressing |
| GSM656297 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | Wnt-1 overexpressing |
| GSM656297 | A375 melanoma cell-line | animals were fed with CsA (50mg/kg/day) | Wnt-1 overexpressing |
| GSM656300 | M24met melanoma cell-line | control | wild type |
| GSM656300 | M24met melanoma cell-line | control | wild type |
| GSM656300 | M24met melanoma cell-line | control | wild type |
| GSM656300 | M24met melanoma cell-line | control | wild type |
| GSM656300 | M24met melanoma cell-line | control | wild type |
| GSM656305 | M24met melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656305 | M24met melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656305 | M24met melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656305 | M24met melanoma cell-line | control | Wnt-1 overexpressing |
| GSM656305 | M24met melanoma cell-line | control | Wnt-1 overexpressing |