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Home › Dataset Library › A Pathobiological Role of the Insulin Receptor in CLL.

Dataset: A Pathobiological Role of the Insulin Receptor in CLL.

Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely...

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Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL with del11q. High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other genomic categories) was confirmed by Q-PCR in 247 CLL cases. INSR protein measurements in 257 CLL cases through FACS, compared with measurements in normal CD19+ B-cells and monocytes, confirmed that a subset of CLL aberrantly expresses high INSR levels. We have employed integrated genomic profiling approaches upon CLL cases with and without del11q to identify 11q-relevant genes. Included are 10 primary human cases with del11q and 9 cases without del11q

Species:
human

Samples:
19

Source:
E-GEOD-26526

PubMed:
21307146

Updated:
Dec.12, 2014

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample 0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS DEL11Q STATUS DELTA CTM INSR-GAPD NET INSR EXPRESSION BY FACS FISH-ALL OF NUCLEI) MEAN
GSM652229 3 del11q present 7.3 7.61% 11q,trisomy 12, 13q 11q,trisomy 12, 13q 13
GSM652230 20 del11q present 6.6 6.01% 6q, 11q 6q, 11q 22
GSM65223 2 del11q present 9.4 7.31% 11q, trisomy 12 11q, trisomy 12 87
GSM652232 6 del11q present 9.3 3.30% 6q, 11q 6q, 11q 32
GSM652233 3 del11q present 5.6 24.55% 11q, 13q 11q, 13q 1
GSM652234 1 del11q present 5.2 40.27% 11q 11q 59
GSM652235 2 del11q present 6.1 28.59% 13q, 11q 13q, 11q 63
GSM652236 2 del11q present absent 5.10% 11q 11q 49
GSM652237 2 del11q present 4.5 37.17% 11q, 13q 11q, 13q 30
GSM652238 2 del11q present 13.4 2.61% 11q, 13q 11q, 13q 7
GSM652239 not specified non-del11q absent 4.32% normal normal 76
GSM652240 not specified non-del11q 13.3 4.36% normal normal 88
GSM65224 not specified non-del11q absent 1.70% normal normal 89
GSM652242 not specified non-del11q absent 4.17% 13q normal 91
GSM652243 1 non-del11q 12.1 5.44% trisomy 12 trisomy 12 56
GSM652244 not specified non-del11q absent 3.30% normal normal 16
GSM652245 not specified non-del11q absent 2.64% normal normal 73
GSM652246 not specified non-del11q absent 1.41% 13q 13q 39
GSM652247 not specified non-del11q 11.9 3.31% normal normal 5

Tags

  • cll
  • insulin
  • protein

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