ArrayExpress Uploader039163del11q present7.37.61%11q,trisomy 12, 13q11q,trisomy 12, 13q1320del11q present6.66.01%6q, 11q6q, 11q222del11q present9.47.31%11q, trisomy 1211q, trisomy 12876del11q present9.33.30%6q, 11q6q, 11q323del11q present5.624.55%11q, 13q11q, 13q11del11q present5.240.27%11q11q592del11q present6.128.59%13q, 11q13q, 11q632del11q presentabsent5.10%11q11q492del11q present4.537.17%11q, 13q11q, 13q302del11q present13.42.61%11q, 13q11q, 13q7not specifiednon-del11qabsent4.32%normalnormal76not specifiednon-del11q13.34.36%normalnormal88not specifiednon-del11qabsent1.70%normalnormal89not specifiednon-del11qabsent4.17%normal13q911non-del11q12.15.44%trisomy 12trisomy 1256not specifiednon-del11qabsent3.30%normalnormal16not specifiednon-del11qabsent2.64%normalnormal73not specifiednon-del11qabsent1.41%13q13q39not specifiednon-del11q11.93.31%normalnormal5arrayexpress_sid4Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely...21307146E-GEOD-26526/profile/8773/arrayexpressuploader719cllinsulinproteinDec.12, 2014Falsea-pathobiological-role-of-the-insulin-receptor-inE-GEOD-26526_A-AFFY-44A Pathobiological Role of the Insulin Receptor in CLL.Sep.15, 2014Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL with del11q. High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other genomic categories) was confirmed by Q-PCR in 247 CLL cases. INSR protein measurements in 257 CLL cases through FACS, compared with measurements in normal CD19+ B-cells and monocytes, confirmed that a subset of CLL aberrantly expresses high INSR levels. We have employed integrated genomic profiling approaches upon CLL cases with and without del11q to identify 11q-relevant genes. Included are 10 primary human cases with del11q and 9 cases without del11qhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26526humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26526/samples/