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Home › Dataset Library › tTA/TDP Mice Expression Array

Dataset: tTA/TDP Mice Expression Array

Transgenic (Tg) mice expressing nuclear or cytoplasmic human TDP-43 were generated. Tg mice had motor spasticity and forebrain...

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Transgenic (Tg) mice expressing nuclear or cytoplasmic human TDP-43 were generated. Tg mice had motor spasticity and forebrain neurodegeneration. Human TDP-43 reduced mouse TDP-43 in nuclei of affected neurons. Tg mice showed alterations in transcripts related to chromatin assembly. Cerebral cortex from 21 transgenic mice and controls were assayed after two weeks off doxycyline diet as described in Igaz et al.

Species:
mouse

Samples:
21

Source:
E-GEOD-25182

Updated:
Dec.12, 2014

Registered:
Nov.24, 2014


Factors: (via ArrayExpress)
Sample MOUSE LINE GENOTYPE SEX
GSM618442 NLS4 +/+
GSM618442 NLS4 +/+
GSM618442 NLS4 +/+
GSM618442 NLS4 +/+
GSM618442 NLS4 +/+
GSM618447 NLS4 +/-
GSM618447 NLS4 +/-
GSM618447 NLS4 +/-
GSM618447 NLS4 +/-
GSM61845 NLS4 -/-
GSM61845 NLS4 -/-
GSM61845 NLS4 -/-
GSM61845 NLS4 -/-
GSM61845 NLS4 -/-
GSM61845 NLS4 -/-
GSM618457 WT12 -/-
GSM618457 WT12 -/-
GSM618459 WT12 +/+
GSM618459 WT12 +/+
GSM618459 WT12 +/+
GSM618459 WT12 +/+

Tags

  • cerebral cortex
  • chromatin
  • cortex
  • forebrain

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